Repeatability of texture features derived from magnetic resonance and computed tomography imaging and use in predictive models for non-small cell lung cancer outcome.

08:00 EDT 12th April 2019 | BioPortfolio

Summary of "Repeatability of texture features derived from magnetic resonance and computed tomography imaging and use in predictive models for non-small cell lung cancer outcome."

To evaluate the repeatability of MRI and CT derived texture features and to investigate the feasibility of use in predictive single and multi-modality models for radiotherapy of non-small cell lung cancer. Methods: Fifty-nine texture features were extracted from unfiltered and wavelet filtered images. Repeatability of test-retest features from helical 4D CT scans, true fast MRI with steady state precession (TRUFISP), and volumetric interpolation breath-hold examination (VIBE) was determined by the concordance correlation coefficient (CCC). A workflow was developed to predict overall survival at 12, 18, and 24 months and tumour response at end of treatment for tumour features, and normal muscle tissue features as a control. Texture features were reduced to repeatable and stable features before clustering. Cluster representative feature selection was performed by univariate or medoid analysis before model selection. P-values were corrected for false discovery rate. Results: Repeatable (CCC ≥ 0.9) features were found for both tumour and normal muscle tissue:
54.4% for tumour and 78.5% for normal tissue,
64.4% for tumour and 67.8% for normal tissue, and
52.6% for tumour and 72.9% for normal muscle tissue. Muscle tissue control analysis found 7 significant models with 6 of 7 models utilizing the univariate representative feature selection technique. Tumour analysis revealed 12 significant models for overall survival and none for tumour response at end of treatment. The accuracy of significant single modality was about the same for MR and CT. Multi-modality tumour models had comparable performance to single modality models. Conclusion: MR derived texture features may add value to predictive models and should be investigated in a larger cohort. Control analysis demonstrated that the medoid representative feature selection method may result in more robust models. .


Journal Details

This article was published in the following journal.

Name: Physics in medicine and biology
ISSN: 1361-6560


DeepDyve research library

PubMed Articles [14758 Associated PubMed Articles listed on BioPortfolio]

MRI based texture analysis to classify low grade gliomas into astrocytoma and 1p/19q codeleted oligodendroglioma.

Texture analysis performed on MR images can detect quantitative features that are imperceptible to human visual assessment. The purpose of this study was to evaluate the feasibility of texture analysi...

Response-to-repeatability of quantitative imaging features for longitudinal response assessment.

<b>Purpose</b> Quantitative imaging biomarkers (QIBs) are often selected and ranked based on their repeatability performance. In the context of treatment response assessment, however,...

Repeatability and Reproducibility of 3D MR Fingerprinting Relaxometry Measurements in Normal Breast Tissue.

The 3D breast magnetic resonance fingerprinting (MRF) technique enables T and T mapping in breast tissues. Combined repeatability and reproducibility studies on breast T and T relaxometry are lacking.

Repeatability of Regional Lung Ventilation Quantification Using Fluorinated (F) Gas Magnetic Resonance Imaging.

To assess the repeatability of global and regional lung ventilation quantification in both healthy subjects and patients with chronic obstructive pulmonary disease (COPD) using fluorinated (F) gas was...

Preoperative prediction of solitary fibrous tumor/hemangiopericytoma and angiomatous meningioma using magnetic resonance imaging texture analysis.

and purpose: Solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) is radiologically difficult to distinguish from meningioma, especially angiomatous meningioma. This study aimed to detect texture par...

Clinical Trials [6151 Associated Clinical Trials listed on BioPortfolio]

Magnetic Resonance Elastography for Assessment of Liver Fibrosis

This study will assess the repeatability of Magnetic Resonance Elastography (MRE) in both healthy volunteers and Hepatitis C Virus-infected patients and lay the groundwork for the validati...

Development of Magnetic Resonance Spectroscopy (MRS) Biomarkers of Tumor Metabolism (MK-0000-145)

This study will evaluate the test-retest repeatability of lactate and other metabolites measured by single voxel magnetic resonance spectroscopy (MRS) and multi-voxel magnetic resonance sp...

Using Magnetic Resonance Spectroscopy With MRI to Non-Invasively Determine Breast Cancer Extent of Disease

The purpose of this study is to evaluate whether high-resolution magnetic resonance imaging of the axilla with spectroscopy can identify nodal features suggestive of metastatic involvement...

Magnetic Resonance Imaging in Evaluating Response to RadiationTherapy in Patients With High Grade Glioma

RATIONALE: Diagnostic procedures, such as magnetic resonance imaging, may help doctors predict a patient's response to treatment and help plan the best treatment. PURPOSE: This clinical tr...

Functional and Anatomical Magnetic Resonance Imaging (MRI) of Chronic Brain Injury and Hyperbaric Oxygen (HBO2) Study Subjects

The purpose of this study is to evaluate Brain MRI (Magnetic Resonance Imaging), and Brain CT (Computed Tomography) Angiogram data in subjects who participate in the "Hyperbaric Oxygen for...

Medical and Biotech [MESH] Definitions

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

Descriptive anatomy based on three-dimensional imaging (IMAGING, THREE-DIMENSIONAL) of the body, organs, and structures using a series of computer multiplane sections, displayed by transverse, coronal, and sagittal analyses. It is essential to accurate interpretation by the radiologist of such techniques as ultrasonic diagnosis, MAGNETIC RESONANCE IMAGING, and computed tomography (TOMOGRAPHY, X-RAY COMPUTED). (From Lane & Sharfaei, Modern Sectional Anatomy, 1992, Preface)

A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.

A type of MAGNETIC RESONANCE IMAGING that uses only one nuclear spin excitation per image and therefore can obtain images in a fraction of a second rather than the minutes required in traditional MRI techniques. It is used in a variety of medical and scientific applications.

An imaging technique using a device which combines TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON and TOMOGRAPHY, X-RAY COMPUTED in the same session.

Quick Search


DeepDyve research library

Relevant Topics

Gilotrif (afatinib)
GILOTRIF (afatinib) is a kinase inhibitor indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L8...

Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...

Asthma COPD Cystic Fibrosis Pneumonia Pulmonary Medicine Respiratory Respiratory tract infections (RTIs) are any infection of the sinuses, throat, airways or lungs.  They're usually caused by viruses, but they can also ...

Searches Linking to this Article