Adrenergic Polymorphisms and Survival in African Americans with Heart Failure: Results from A-HeFT.

08:00 EDT 9th April 2019 | BioPortfolio

Summary of "Adrenergic Polymorphisms and Survival in African Americans with Heart Failure: Results from A-HeFT."

Polymorphisms in adrenergic signaling affect the molecular function of adrenergic receptors and related proteins. The β1 adrenergic receptor (ADRB1) Arg389Gly, G-protein receptor kinase type 5 (GRK5) Gln41Leu, G-protein β-3 subunit (GNB3) 825 C/T, and α2c deletion affect adrenergic tone, impact heart failure outcomes and differ in prevalence by ethnicity. Their combined effect within black cohorts remains unknown.


Journal Details

This article was published in the following journal.

Name: Journal of cardiac failure
ISSN: 1532-8414


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