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Atomistic modeling and molecular dynamics analysis of human Ca1.2 channel using external electric field and ion pulling simulations.

08:00 EDT 9th April 2019 | BioPortfolio

Summary of "Atomistic modeling and molecular dynamics analysis of human Ca1.2 channel using external electric field and ion pulling simulations."

Human Ca1.2 (hCav1.2), a calcium selective voltage-gated channel, plays important roles in normal cardiac and neuronal functions. Calcium influx and gating mechanisms leading to the activation of hCa1.2 are critical for its functionalities. Lack of an experimentally resolved structure of hCa1.2 remains a significant impediment in molecular-level understanding of this channel. This work focuses on building atomistic hCa1.2 model and studying calcium influx using computational approaches.

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This article was published in the following journal.

Name: Biochimica et biophysica acta. General subjects
ISSN: 1872-8006
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