Advertisement

Topics

In vivo assembly of eukaryotic signal recognition particle: a still enigmatic process involving the SMN complex.

08:00 EDT 9th April 2019 | BioPortfolio

Summary of "In vivo assembly of eukaryotic signal recognition particle: a still enigmatic process involving the SMN complex."

The signal recognition particle (SRP) is a universally conserved non-coding ribonucleoprotein complex that is essential for targeting transmembrane and secretory proteins to the endoplasmic reticulum. Its composition and size varied during evolution. In mammals, SRP contains one RNA molecule, 7SL RNA, and six proteins: SRP9, 14, 19, 54, 68 and 72. Despite a very good understanding of the SRP structure and of the SRP assembly in vitro, how SRP is assembled in vivo remains largely enigmatic. Here we review current knowledge on how the 7SL RNA is assembled with core proteins to form functional RNP particles in cells. SRP biogenesis is believed to take place both in the nucleolus and in the cytoplasm and to rely on the survival of motor neuron complex, whose defect leads to spinal muscular atrophy.

Affiliation

Journal Details

This article was published in the following journal.

Name: Biochimie
ISSN: 1638-6183
Pages:

Links

DeepDyve research library

PubMed Articles [13956 Associated PubMed Articles listed on BioPortfolio]

A case of dermatomyositis with the anti-signal recognition particle antibody that was successfully treated with prednisolone and intravenous immunoglobulin therapy.

Dynamic Assembly of Microspheres under an Ultrasound Field.

The assembly of micro-nanoparticles is one of the key tasks for controlling and manipulating the structure of materials at micro/-nanoscale. By carefully designing the ultrasound experiments and compa...

Experimental evaluation of coevolution in a self-assembling particle.

Protein evolution occurs via restricted evolutionary paths that are influenced by both previous and subsequent mutations. This effect, termed epistasis, is critical in population genetics, drug resist...

Zebrafish as a predictive screening model to assess macrophage clearance of liposomes in vivo.

Macrophage recognition of nanoparticles is highly influenced by particle size and surface modification. Due to the lack of appropriate in vivo screening models, it is still challenging and time-consum...

Self-assembly of intramolecularly hydrogen-bonded amphiphilic diboronic acid for saccharide recognition.

The designed organic boronic acid molecule featuring both hydrophilic and hydrophobic moieties, makes a potential functional surfactant. Selective recognition of saccharides through morphological chan...

Clinical Trials [1975 Associated Clinical Trials listed on BioPortfolio]

Clinical Investigation to Evaluate the Haemonetics POLFA Modified Sample Needle Assembly With Vacuum Tube Holder

This study evaluates whether whole blood transferred through the new POLFA needle assembly meets supernatant hemoglobin acceptability standards.

The Mechanism of Melanocyte Self-Assembly on Biomaterials and the Functional Analysis

The aim of this study is to survey melanocytes in the ability of self-assembly on biomaterials and functional analysis in vitro. Also, this study may provide a better way for treatment of ...

The Influence of Bone Allograft Particle Sizes on the Quantity and Quality of New Bone Formation in Grafted Extraction Sockets and Edentulous Ridges

This study will evaluate the effect of allograft bone particle size on the bone quantity and quality following socket grafting and lateral ridge augmentation in preparation for endosseous ...

In Vivo Wear of All-ceramic and Metal-ceramic Crowns and Their Enamel Antagonists After Three Years

This study aims determine the wear rates of enamel versus enamel and enamel versus ceramic in human beings in relation to the microstructure of the ceramic material. Specific aims of the ...

TLD-1, a Novel Liposomal Doxorubicin, in Patients With Advanced Solid Tumors

TLD-1 is a novel liposomal formulation of doxorubicin (PEG surface) that compared favorably to conventional liposomal formulations of doxorubicin including Caelyx® in preclinical in vivo ...

Medical and Biotech [MESH] Definitions

Complexes of scRNA (RNA, SMALL CYTOPLASMIC) and protein found in the cytoplasm. An example is SIGNAL RECOGNITION PARTICLE.

A cytosolic ribonucleoprotein complex that acts to induce elongation arrest of nascent presecretory and membrane proteins until the ribosome becomes associated with the rough endoplasmic reticulum. It consists of a 7S RNA and at least six polypeptide subunits (relative molecular masses 9, 14, 19, 54, 68, and 72K).

The Alu sequence family (named for the restriction endonuclease cleavage enzyme Alu I) is the most highly repeated interspersed repeat element in humans (over a million copies). It is derived from the 7SL RNA component of the SIGNAL RECOGNITION PARTICLE and contains an RNA polymerase III promoter. Transposition of this element into coding and regulatory regions of genes is responsible for many heritable diseases.

Highly repeated sequences, 100-300 bases long, which contain RNA polymerase III promoters. The primate Alu (ALU ELEMENTS) and the rodent B1 SINEs are derived from 7SL RNA, the RNA component of the signal recognition particle. Most other SINEs are derived from tRNAs including the MIRs (mammalian-wide interspersed repeats).

The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Searches Linking to this Article