Allergy to Mus m 1: Allergy to Mus m 1: a review of structural, and immunological features.

08:00 EDT 9th April 2019 | BioPortfolio

Summary of "Allergy to Mus m 1: Allergy to Mus m 1: a review of structural, and immunological features."

The prevalence of allergies to pets has been increasing over the past decades. Some of the most important animal-derived allergens are members of the lipocalin protein family, which are found in dander, saliva, and urine. These allergens disperse effectively and are widely present in indoor environments. Exposure to high levels of mouse urinary protein (Mus m 1, hereinafter called 'mouse allergen') has been previously linked to sensitization to mouse, and indicators of asthma severity or control in some studies. To date, this is the only known mouse allergen registered in the IUIS database. This allergen is responsible for 27% of the total T cell response, confirming the dominant role it plays in mouse allergy. Mice have a worldwide distribution affecting both rural and urban areas; hence humans are frequently exposed to mouse-derived proteins. Additionally, exposure to mouse allergens has increased since they are more frequently being made pets, and in addition, exposure of laboratory animal care personnel to mice has been associated with a high risk of developing occupational allergies. Mus m 1 has been recognized as the main mouse allergen, and several studies suggest its clinical relevance. What makes Mus m 1 such an important allergen? In this review, we explored its structural, immunological, and clinical features.


Journal Details

This article was published in the following journal.

Name: Immunology letters
ISSN: 1879-0542


DeepDyve research library

PubMed Articles [21446 Associated PubMed Articles listed on BioPortfolio]

Chlorhexidine Allergy: On the Rise and Often Overlooked.

In recent years, the risk of allergy to chlorhexidine is increasingly recognised. In this review, we discuss why the allergy is so easily overlooked and point out several preventative initiatives that...

Novel cutaneous mediators of chemical allergy.

Chemical allergy can manifest into allergic contact dermatitis and asthma and the importance of skin sensitization in both of these diseases is increasingly being recognized. Given the unique characte...

Red meat allergy in children and adults.

To highlight recent advances in our understanding of the clinical features, prevalence, and pathophysiology of red meat allergy.

Economic burden of food allergy- A systematic review.

Age at introduction to complementary solid food and food allergy and sensitization: a systematic review and meta-analysis.

An infant's age at introduction of complementary solids may contribute to food allergy. We aimed to synthesize the literature on the association between age at introduction of complementary solids, ex...

Clinical Trials [3843 Associated Clinical Trials listed on BioPortfolio]

De-labeling of Patients With False Diagnosis of Penicillin Allergy

The purpose of this study is to estimate the prevalence of penicillin allergy, evaluate the diagnostic value of the allergologic work-up used in the study, and the health effects of penici...

The Influence of Early and Continuous Exposure of Infants to Cow's Milk Formula on the Prevention of Milk Allergy

Cow's milk protein (CMP) allergy is one of the most common food allergies and potentially a fatal one. Early feeding with CMP has been considered in the past as a risk factor for developme...

A Study of ASP4070 to Confirm Safety and Immunological Response in Patients With Pollen Allergy

Examine safety and immunological response for ASP4070 when vaccinated in patients with pollen allergy

Anti-TSLP (AMG 157) Plus Antigen-Specific Immunotherapy for Induction of Tolerance in Individuals With Cat Allergy

The purpose of this research study is to find out if cat allergy shots with combination with AMG 157, an experimental medication, will help the cat allergy shots work after just one year o...

Effectiveness of Cat-PAD to Treat Cat Allergy in Cat Allergic Subjects

Cat allergy is an increasingly prevalent condition, affecting 10-15% of patients with allergic rhinoconjunctivitis and/or asthma. Cat-PAD is a novel, synthetic, allergen-derived peptide d...

Medical and Biotech [MESH] Definitions

A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.

A method of treating an ALLERGY by administering ALLERGENS, in liquid formulation or tablets, to the ORAL MUCOSA under the tongue.

A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.

A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.

The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

Quick Search


DeepDyve research library

Relevant Topic

The term allergy is used to describe a response, within the body, to a substance, which is not necessarily harmful in itself, but results in an immune response and a reaction that causes symptoms and disease in a predisposed person, which in turn can cau...

Searches Linking to this Article