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Supporting the heart: functions of the cardiomyocyte's non-sarcomeric cytoskeleton.

08:00 EDT 9th April 2019 | BioPortfolio

Summary of "Supporting the heart: functions of the cardiomyocyte's non-sarcomeric cytoskeleton."

The non-contractile cytoskeleton in cardiomyocytes is comprised of cytoplasmic actin, microtubules, and intermediate filaments. In addition to providing mechanical support to these cells, these structures are important effectors of tension-sensing and signal transduction and also provide networks for the transport of proteins and organelles. The majority of our knowledge on the function and structure of these cytoskeletal networks comes from research on proliferative cell types. However, in recent years, researchers have begun to show that there are important cardiomyocyte-specific functions of the cytoskeleton. Here we will discuss the current state of cytoskeletal biology in cardiomyocytes, as well as research from other cell types, that together suggest there is a wealth of knowledge on cardiac health and disease waiting to be uncovered through exploration of the complex signaling networks of cardiomyocyte non-sarcomeric cytoskeletal proteins.

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This article was published in the following journal.

Name: Journal of molecular and cellular cardiology
ISSN: 1095-8584
Pages:

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Medical and Biotech [MESH] Definitions

A plakin characterized by repeat sequences homologous to SPECTRIN and PLECTIN and C-terminal EF HAND MOTIFS. It functions as an integrator of INTERMEDIATE FILAMENTS, ACTIN and MICROTUBULES in cytoskeleton networks. It is required for anchoring intermediate filaments to the actin cytoskeleton in neural and muscle cells as well as anchoring KERATIN-containing intermediate filaments to HEMIDESMOSOMES in EPITHELIAL CELLS.

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The biological science concerned with the life-supporting properties, functions, and processes of living organisms or their parts.

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