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Asthma is a chronic inflammatory disease of the airways with a complex pathophysiology, making the development of diagnostic and therapeutic tools a challenge. Exosomes are extracellular membranous nanovesicles implicated in intercellular communication. Exosome composition and cargo are highly heterogeneous depending on their cellular origin and physiological state. They contain proteins (tetraspanins, heat-shock proteins), nucleic acids (RNA, microRNA), and lipids (ceramides, cholesterol, sphingolipids). Current scientific advances show that exosomes play a pivotal role in the pathology of asthma as well as other inflammatory diseases, and all types of inflammatory cells (neutrophils, dendritic cells, lymphocytes, eosinophils) release exosomes. Also, structural lung cells such as airway epithelial cells and airway smooth muscle cells produce and secrete these nanovesicles. Exosomes influence and modify the functionality of these inflammatory and structural cells, triggering the characteristic processes of asthma disease. Additionally, exosomes are used as biomarkers in several disorders because they are easier to collect from different biofluids, making them a non-invasive method for screening human pathologies. Also, due to their special molecular characteristics, they can be loaded with different molecules and employed as a drug-delivery vehicle. This review focuses on recent advances related to the role of exosomes in asthma disease.
This article was published in the following journal.
Name: Clinica chimica acta; international journal of clinical chemistry
Exosomes are newly recognized natural nanocarrier and intercellular messenger that emerge as important mediators of signal transmission. Exosomes have been reported to modulate the inflammatory respon...
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The application of pathology to questions of law.
A field of anatomical pathology in which living tissue is surgically removed for the purpose of diagnosis and treatment.
A subspecialty of pathology concerned with the molecular basis (e.g., mutations) of various diseases.
A dental specialty concerned with pathology of the oral cavity.
A subspecialty of pathology applied to the solution of clinical problems, especially the use of laboratory methods in clinical diagnosis. (Dorland, 28th ed.)
Pulmonary relating to or associated with the lungs eg Asthma, chronic bronchitis, emphysema, COPD, Cystic Fibrosis, Influenza, Lung Cancer, Pneumonia, Pulmonary Arterial Hypertension, Sleep Disorders etc Follow and track Lung Cancer News ...
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