Risks and benefits of corticosteroids in arthritic diseases in the clinic.

08:00 EDT 9th April 2019 | BioPortfolio

Summary of "Risks and benefits of corticosteroids in arthritic diseases in the clinic."

Glucocorticoids (GCs) constitute a first line treatment for many autoimmune and inflammatory diseases. Due to their potent anti-inflammatory and immunosuppressive actions, GCs are added frequently to disease modifying antirheumatic drugs (DMARDs) in various arthritic diseases, such as rheumatoid arthritis. However, their prolonged administration or administration at high doses is associated with adverse effects that may be (quality of) life-threatening, including osteoporosis, metabolic, gastrointestinal and cardiovascular side effects. In this review, we summarize the clinical and pharmacological effects of GCs in different arthritic diseases, while documenting the current research efforts towards the identification of novel and more efficient GCs with reduced side effects.


Journal Details

This article was published in the following journal.

Name: Biochemical pharmacology
ISSN: 1873-2968


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Medical and Biotech [MESH] Definitions

An indicator of the benefits and risks of treatment.

The condition in which reasonable knowledge regarding risks, benefits, or the future is not available.

Inflammation of the SPINE. This includes both arthritic and non-arthritic conditions.

A condition or factor associated with a recipient that makes the use of a drug, procedure, or physical agent improper or inadvisable. Contraindications may be absolute (life threatening) or relative (higher risk of complications in which benefits may outweigh risks).

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