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A biocompatible hydrogel containing hexa-peptide as key unit has been designed and fabricated. Our design construct comprises a β-sheet rich short hexa-peptide in the centre with a hydrophobic long chain and hydrophilic triple lysine unit attached at the N- and C- terminals respectively. Thus, it is this amphiphilic nature of the molecule that facilitates the gelation. It can capture solvent molecules in the three dimensional cross-linked fibrillary networks. The amphiphilic character of the construct has been modulated to produce an excellent biocompatible soft-material for the inhibition of bacterial growth by rupturing the bacterial cell membrane. This hydrogel is also stable against the enzymatic degradation (Proteinase K) and most importantly offers a bio-compatible environment for the growth of normal mammalian cells due to its non-cytotoxic nature as observed through the cell viability assay. From the haemolytic assay, the morphology of the hRBCs is found to be almost intact, which suggests that the hydrogel can be used in biomedical applications. Thus, this newly designed anti-bacterial hydrogel can be used both as antibacterial biomaterials and biocompatible scaffolds for mammalian cell culture.
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Antibiotics and photodynamic therapy (PDT) are widely employed in curing acne. However, antibiotics as an effective treatment would lead to bacterial resistance and severe side effects. In this study,...
The creation of a moist environment and promotion of cell proliferation and migration together with antibacterial property are critical to the wound-healing process. Alginate (Alg) is an excellent can...
In the current study, hard water softening for the removal of Ca and Mg ions was performed using hydrogel beads based on Gum Tragacance (GT) modified by using 2-acrylamido-2-methyl-1-propanesulfonic a...
Graphene hydrogels hold great potential for the disinfection of bacteria-contaminated water. However, the intrinsic antibacterial activity of graphene hydrogels is not satisfactory, and the incorporat...
In the field of ophthalmology, postoperative endophthalmitis (POE) is a serious surgical complication, which may lead to poor visual outcome even after the infection has been controlled. In the study,...
To evaluate an HIV synthetic lipopeptide candidate vaccine component, P3C541b, at two dose levels, administered subcutaneously (s.c.) in a randomized, double-blind, placebo controlled stud...
To evaluate an HIV lipopeptide immunotherapeutic, P3C541b, at two dose levels administered subcutaneously in HIV-seropositive patients.
This small feasibility study will evaluate the use of hydrogel electrode pads (rather than tap water baths) to deliver iontophoresis treatment using a traditional iontophoresis device. Par...
The aim of this non-dispensing fitting study is to evaluate the subjective comfort, lens handling, lens fitting characteristics and visual acuity of different hydrogel lens designs versus ...
The purpose of this study is to determine if topical application of a hydrogel that contains plant extracts will improve healing of diabetic foot ulcers when compared to treatment with a h...
A cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.
A network of cross-linked hydrophilic macromolecules used in biomedical applications.
Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.
Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.
Basic lipopeptide antibiotic group obtained from Bacillus polymyxa. They affect the cell membrane by detergent action and may cause neuromuscular and kidney damage. At least eleven different members of the polymyxin group have been identified, each designated by a letter.
An assay is an analytic procedure for qualitatively assessing or quantitatively measuring the presence or amount or the functional activity of a target entity. This can be a drug or biochemical substance or a cell in an organism or organic sample. ...