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Biocompatible Lipopeptide-Based Antibacterial Hydrogel.

08:00 EDT 12th April 2019 | BioPortfolio

Summary of "Biocompatible Lipopeptide-Based Antibacterial Hydrogel."

A biocompatible hydrogel containing hexa-peptide as key unit has been designed and fabricated. Our design construct comprises a β-sheet rich short hexa-peptide in the centre with a hydrophobic long chain and hydrophilic triple lysine unit attached at the N- and C- terminals respectively. Thus, it is this amphiphilic nature of the molecule that facilitates the gelation. It can capture solvent molecules in the three dimensional cross-linked fibrillary networks. The amphiphilic character of the construct has been modulated to produce an excellent biocompatible soft-material for the inhibition of bacterial growth by rupturing the bacterial cell membrane. This hydrogel is also stable against the enzymatic degradation (Proteinase K) and most importantly offers a bio-compatible environment for the growth of normal mammalian cells due to its non-cytotoxic nature as observed through the cell viability assay. From the haemolytic assay, the morphology of the hRBCs is found to be almost intact, which suggests that the hydrogel can be used in biomedical applications. Thus, this newly designed anti-bacterial hydrogel can be used both as antibacterial biomaterials and biocompatible scaffolds for mammalian cell culture.

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This article was published in the following journal.

Name: Biomacromolecules
ISSN: 1526-4602
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Medical and Biotech [MESH] Definitions

A cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.

A network of cross-linked hydrophilic macromolecules used in biomedical applications.

Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.

Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.

Basic lipopeptide antibiotic group obtained from Bacillus polymyxa. They affect the cell membrane by detergent action and may cause neuromuscular and kidney damage. At least eleven different members of the polymyxin group have been identified, each designated by a letter.

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