Association of serum deiodinase type 2 level with chronic obstructive pulmonary disease in the Polish population.

08:00 EDT 12th April 2019 | BioPortfolio

Summary of "Association of serum deiodinase type 2 level with chronic obstructive pulmonary disease in the Polish population."

Deiodinase type 2 (DIO2) is a selenoenzyme involved in the synthesis of thyroid hormones. Chemerin is a newly investigated adipokine known also as novel chemokine. Both molecules have been recently expected and found to play an important role in inflammation and immunity. DIO2, for example, is upregulated during acute and chronic inflammation. In addition, inflammation-induced expression of DIO2 in macrophages has been confirmed, while chemerin modulates the activation and chemotaxis of immune cells. It is widely known that chronic obstructive pulmonary disease (COPD) - the most common lung disease in the world - is accompanied by an inflammatory process and immune activation. There are no studies demonstrating an association between DIO2, chemerin and COPD. The aim of this study was to estimate DIO2 and chemerin concentration in serum collected from patients suffering from COPD and to compare it with healthy subjects, as well as to correlate with basic and clinical characteristics.


Journal Details

This article was published in the following journal.

Name: Acta biochimica Polonica
ISSN: 1734-154X


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