Inhibition of jejunal protein synthesis and breakdown in Pseudomonas aeruginosa induced sepsis pig model.

08:00 EDT 12th April 2019 | BioPortfolio

Summary of "Inhibition of jejunal protein synthesis and breakdown in Pseudomonas aeruginosa induced sepsis pig model."

Maintenance of gut integrity has long been recognized as crucial for survival in sepsis but alterations in protein metabolism have not previously been documented. Therefore in the present study, we measured in a Pseudomonas aeruginosa induced porcine sepsis model, fractional protein synthesis (FSR) and breakdown rates (FBR) in jejunal mucosa in a fasted conscious state.


Journal Details

This article was published in the following journal.

Name: American journal of physiology. Gastrointestinal and liver physiology
ISSN: 1522-1547


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Medical and Biotech [MESH] Definitions

A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.

Bacteriocins elaborated by mutant strains of Pseudomonas aeruginosa. They are protein or protein-lipopolysaccharide complexes lethal to other strains of the same or related species.

Antibiotic pigment produced by Pseudomonas aeruginosa.

A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.

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