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Controllable Covalent-bound Nano-Architectures from DNA Frames.

08:00 EDT 12th April 2019 | BioPortfolio

Summary of "Controllable Covalent-bound Nano-Architectures from DNA Frames."

Could one manipulate nanoscale building blocks using chemical reactions like molecular synthesis to yield new supra-nanoscale objects? The precise control over the final architecture might be challenging due to the size mismatch of molecularly-scaled reactive functional groups and nanoscale building blocks, which limits a control over the valence and specific locations of reaction spots. Taking advantage of programmable octahedral DNA frame, we report a facile approach of engineering chemical reactions between nanoscale building blocks toward formation of controlled nano-architectures. Azide and alkyne moieties were specifically anchored onto desired vertices of DNA frames, providing chemically reactive nano-constructs with directionally-defined valence. Akin to the conventional molecular reactions, the formation of a variety of nanoscale architectures was readily achieved upon mixing of the frames with the different reactive valence and at different stoichiometric ratios. This strategy may open a door for a programmable synthesis of supra-nanoscale structures with complex architectures and diversified functions.

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This article was published in the following journal.

Name: Journal of the American Chemical Society
ISSN: 1520-5126
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