Advertisement

Topics

Perylene Bisimide Aggregates as Probes for Sub-Nanomolar Discrimination of Aromatic Biogenic Amines.

08:00 EDT 12th April 2019 | BioPortfolio

Summary of "Perylene Bisimide Aggregates as Probes for Sub-Nanomolar Discrimination of Aromatic Biogenic Amines."

Perylene Bisimide (PBI) derivatives show peculiar physical chemical features, such as a highly conjugated system, high extinction coefficients and elevated fluorescence quantum yields, making them suitable for the development of optical sensors of compounds of interest. In particular, they are characterized by the tendency to aggregate into π-π stacked supramolecular structures. In this contribution, the behavior of the PBI derivative N,N'-bis(2-(trimethylammonium)ethylene)perylene bisimide dichloride was investigated both in aqueous solution and on solid support. The electronic communication among PBI aggregates and biogenic amines was exploited in order to discriminate aromatic amines down to sub-nanomolar concentrations by observing PBI fluorescence variations in presence of various amines and at different concentrations. The experimental findings were corroborated by DFT calculations. In particular, phenylethylamine and tyramine were demonstrated to be selectively detected down to 10-10 M concentration. Then, in order to develop a Surface Plasmon Resonance (SPR) device, PBI was deposited onto a SPR support by means of the layer-by-layer method. The PBI was deposited in the aggregated form and was demonstrated to preserve the capability to discriminate, selectively and with an outstanding analytical sensitivity, tyramine in vapor phase and even if mixed with other aromatic amines.

Affiliation

Journal Details

This article was published in the following journal.

Name: ACS applied materials & interfaces
ISSN: 1944-8252
Pages:

Links

DeepDyve research library

PubMed Articles [3339 Associated PubMed Articles listed on BioPortfolio]

Sedimentary archive of Polycyclic Aromatic Hydrocarbons and perylene sources in the northern part of Taihu Lake, China.

In the present work, we analyzed the concentration patterns of 20 Polycyclic Aromatic Hydrocarbons (PAHs) in 25 surface sediments and 11 sediment cores from the northern part of Taihu Lake, China. Thr...

Colloidal Quantum Dot Arrangement Assisted by Perylene Bisimide Self-Assembly.

Colloidal semiconductor nanocrystals, so-called quantum dots (QDs), are attractive as molecular-like smart nanomaterials, and their emission and optoelectronic properties in the dispersed state have b...

Solvent-Modulated Charge-Transfer Resonance Enhancement in the Excimer State of a Bay-Substituted Perylene Bisimide Cyclophane.

Excimer, a configurational mixing between Frenkel exciton and charge transfer resonance states, is typically regarded as a trap state that hinders desired energy or charge transfer processes in artifi...

CTAB-triggered Ag aggregates for reproducible SERS analysis of urinary polycyclic aromatic hydrocarbon metabolites.

We propose a novel method for highly sensitive SERS detection of hydrophobic analytes based on cetyltrimethylammonium bromide (CTAB)-triggered Ag aggregates. In particular, we demonstrated its use in ...

In Vivo Synthesis of Nanocomposites Using the Recombinant Escherichia coli.

Biogenic gold nanorod (AuNR)-Ag core-shell nanocomposites (NCs) are synthesized by using recombinant Escherichia coli to demonstrate in vivo synthesis of biogenic NCs for the first time. The chemicall...

Clinical Trials [274 Associated Clinical Trials listed on BioPortfolio]

Platelet Leukocyte Aggregates in Acute Cardiac Syndrome vs Healthy Volunteers

This project aims to refine previous studies including the investigators work recently published in August 2012 Journal Thrombosis and Thrombolysis. That study showed a relationship betwee...

Aromatic Amino Acid Metabolism in the Pathogenesis of Kwashiorkor

This research may explain whether a shortage of three special compounds called aromatic amino acids is responsible for the severe illness and high death rate of children with the kwashiork...

Treatment of Acute Pharyngo-Tonsillitis With Essential Oils of Aromatic Plants

This randomized, double blind, parallel group study, compared the efficacy of spray containing aromatic essential oils of some herbal plants, against placebo in the treatment of patients w...

Determining Total Aromatic Amino Acid Requirements in Pregnant Women

Phenylalanine and tyrosine are aromatic amino acids that people need to obtain in their diets. Amino acids are the building blocks for protein, are are therefore required to form tissues i...

A Clinical Trial for Treatment of Aromatic L-amino Acid Decarboxylase (AADC) Deficiency Using AAV2-hAADC - An Expansion

This clinical trial expansion is to offer patients, who are not enrolled into the Phase I/II trial, a chance of treatment, to extend the experience in this gene therapy, and to increase th...

Medical and Biotech [MESH] Definitions

RNA, usually prepared by transcription from cloned DNA, which complements a specific mRNA or DNA and is generally used for studies of virus genes, distribution of specific RNA in tissues and cells, integration of viral DNA into genomes, transcription, etc. Whereas DNA PROBES are preferred for use at a more macroscopic level for detection of the presence of DNA/RNA from specific species or subspecies, RNA probes are preferred for genetic studies. Conventional labels for the RNA probe include radioisotope labels 32P and 125I and the chemical label biotin. RNA probes may be further divided by category into plus-sense RNA probes, minus-sense RNA probes, and antisense RNA probes.

Cell surface proteins that bind biogenic amines with high affinity and regulate intracellular signals which influence the behavior of cells. Biogenic amine is a chemically imprecise term which, by convention, includes the catecholamines epinephrine, norepinephrine, and dopamine, the indoleamine serotonin, the imidazolamine histamine, and compounds closely related to each of these.

A DNA amplification technique based upon the ligation of OLIGONUCLEOTIDE PROBES. The probes are designed to exactly match two adjacent sequences of a specific target DNA. The chain reaction is repeated in three steps in the presence of excess probe: (1) heat denaturation of double-stranded DNA, (2) annealing of probes to target DNA, and (3) joining of the probes by thermostable DNA ligase. After the reaction is repeated for 20-30 cycles the production of ligated probe is measured.

DNA probes specific for the identification of human papilloma virus.

A technique for visualizing CHROMOSOME ABERRATIONS using fluorescently labeled DNA probes which are hybridized to chromosomal DNA. Multiple fluorochromes may be attached to the probes. Upon hybridization, this produces a multicolored, or painted, effect with a unique color at each site of hybridization. This technique may also be used to identify cross-species homology by labeling probes from one species for hybridization with chromosomes from another species.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Searches Linking to this Article