Dual Near-Infrared Emissive Luminescent Nanoprobe for Ratiometric Luminescent Monitoring of ClO in Living Organisms.

08:00 EDT 12th April 2019 | BioPortfolio

Summary of "Dual Near-Infrared Emissive Luminescent Nanoprobe for Ratiometric Luminescent Monitoring of ClO in Living Organisms."

The difficulty of near-infrared (NIR) ratiometric detection imaging lies in the lack of high-efficiency NIR probes and the overlapping interference between two emission peaks. To achieve more accurate detecting in living organisms, dual near-infrared emissive luminescent nanoprobe was designed under the same excitation at 808 nm. The Er ions doped nanoparticles were employed as reference with its fluorescence emission at 1525 nm. Meanwhile, a cyanine dye molecule (Cy925) was combined on the surface of nanoparticles as ClO recognition site with its NIR emission at 925 nm. The ratiometric nanoprobe relied on the ratio of aforementioned two separated NIR peaks (I/I), featuring deeper imaging penetration depth and low auto-fluorescence. This nanoprobe was verified to be sensitive and highly selective to ClO through photoluminescence titration. The in vitro detection experiment developed reasonable work curves guarantee that we can detect the change in concentration of ClO in mice limbs with arthritis through in vivo imaging experiment.


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This article was published in the following journal.

Name: ACS applied materials & interfaces
ISSN: 1944-8252


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