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The difficulty of near-infrared (NIR) ratiometric detection imaging lies in the lack of high-efficiency NIR probes and the overlapping interference between two emission peaks. To achieve more accurate detecting in living organisms, dual near-infrared emissive luminescent nanoprobe was designed under the same excitation at 808 nm. The Er ions doped nanoparticles were employed as reference with its fluorescence emission at 1525 nm. Meanwhile, a cyanine dye molecule (Cy925) was combined on the surface of nanoparticles as ClO recognition site with its NIR emission at 925 nm. The ratiometric nanoprobe relied on the ratio of aforementioned two separated NIR peaks (I/I), featuring deeper imaging penetration depth and low auto-fluorescence. This nanoprobe was verified to be sensitive and highly selective to ClO through photoluminescence titration. The in vitro detection experiment developed reasonable work curves guarantee that we can detect the change in concentration of ClO in mice limbs with arthritis through in vivo imaging experiment.
This article was published in the following journal.
Name: ACS applied materials & interfaces
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Techniques using light resulting from PHYSICAL LUMINESCENCE emitted by LUMINESCENT PROTEINS and LUMINESCENT AGENTS.
Compound such as LUMINESCENT PROTEINS that cause or emit light (PHYSICAL LUMINESCENCE).
Measurement of light resulting from PHYSICAL CHEMILUMINESCENCE such as from LUMINESCENT PROTEINS and LUMINESCENT AGENTS.
Emission of LIGHT when ELECTRONS return to the electronic ground state from an excited state and lose the energy as PHOTONS. It is sometimes called cool light in contrast to INCANDESCENCE. LUMINESCENT MEASUREMENTS take advantage of this type of light emitted from LUMINESCENT AGENTS.
Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.
Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...