Ordering effect of protein surfaces on water dynamics: NMR relaxation study.

08:00 EDT 8th April 2019 | BioPortfolio

Summary of "Ordering effect of protein surfaces on water dynamics: NMR relaxation study."

Proteins in solution affect the structural and dynamic properties of the bulk water at the protein-water interface, resulting in a contribution to the order of the hydration water. Theoretical and experimental NMR relaxation methods were developed to study the dynamic properties of water molecules in the protein hydration shell. Water non-selective and selective relaxation rates, were shown to be sensitive to contributions from ordered solvent molecules at protein surface. The average rotational correlation time of water molecules in the protein hydration shell was determined for three protein systems of different size: ribonuclease A, human serum albumin and fibrinogen. The knowledge of these properties is an important step toward the determination of the size of the water ordering contributions originate in proteins systems.


Journal Details

This article was published in the following journal.

Name: Biophysical chemistry
ISSN: 1873-4200
Pages: 106149


DeepDyve research library

PubMed Articles [44994 Associated PubMed Articles listed on BioPortfolio]

Protein-polymer dynamics as affected by polymer coating and interactions.

We investigate the relaxation dynamics of protein-polymer conjugates by neutron scattering spectroscopy to understand to which extent the coating of a protein by a polymer can replace water in promoti...

Enhancing Dynamics of Water Confined between Graphene Oxide Surfaces with Janus Interfaces: A Molecular Dynamics Study.

Graphene oxide membranes have been widely studied for their potential applications in water desalination applications. In order to understand the influence of surface oxidation and the inherent hetero...

Counterion Effect on Vibrational Relaxation and the Rotational Dynamics of Interfacial Water and an Anionic Vibrational Probe in the Confined Reverse Micelles Environment.

Vibrational relaxation and the rotational dynamics of water molecules encapsulated in reverse micelles (RMs) have been investigated by ultrafast infrared (IR) spectroscopy and two-dimensional IR (2D I...

On the influence of wetting behaviour on relaxation of adsorbed liquids - A combined NMR, EPR and DNP study of aged rocks.

The influence of wettability modification in natural rocks has been studied by means of NMR relaxation dispersion of water and several organic liquids, employing H, F and H relaxometry. Berea, Benthei...

Factors Promoting the Formation of Clathrate-like Ordering of Water in Biomolecular Structure at Ambient Temperature and Pressure.

Clathrate-hydrate forms when a hydrophobic molecule is entrapped inside a water cage or cavity. Although biomolecular structures also have hydrophobic patches, clathrate-like water is found in only a ...

Clinical Trials [7610 Associated Clinical Trials listed on BioPortfolio]

Impact of Nerve-sparing Radical Hysterectomy on Patients' Urinary Dynamics

Background: Radical hysterectomy is an important therapy for early cervical cancer. Disfunction of urinary dynamics is the most common postoperative adverse effects, which had negative imp...

Protein Ingestion and Muscle Carnitine Uptake

The purpose of this study is to assess the effects of a protein-carbohydrate beverage on the absorption of an orally ingested bolus of L-carnitine, compared to flavoured water and carbohyd...

C-reactive Protein Information and Blood Cultures for Emergency Department Patients With Sepsis

Patients with sepsis (2 or more systemic inflammatory response syndrome criteria and suspected infection) assessed in the emergency department have blood cultures obtained to identify pote...

Time,Self and Spontaneous Mental Activities in Patients With Psychotic Disorders

The main purpose of the study is to examine to which extent abnormalities in the dynamics of neural activities observed in patients with psychosis is related to difficulties at ordering si...

Effect of the Subconscious on Mohs Micrographic Surgery

The goal of this study is to determine if relaxation therapy improves patient satisfaction with Mohs micrographic surgery.

Medical and Biotech [MESH] Definitions

A replica technique in which cells are frozen to a very low temperature and cracked with a knife blade to expose the interior surfaces of the cells or cell membranes. The cracked cell surfaces are then freeze-dried to expose their constituents. The surfaces are now ready for shadowing to be viewed using an electron microscope. This method differs from freeze-fracturing in that no cryoprotectant is used and, thus, allows for the sublimation of water during the freeze-drying process to etch the surfaces.

The study of the energy of electrons ejected from matter by the photoelectric effect, i.e., as a direct result of absorption of energy from electromagnetic radiation. As the energies of the electrons are characteristic of a specific element, the measurement of the energy of these electrons is a technique used to determine the chemical composition of surfaces.

Factors that modify the effect of the putative causal factor(s) under study.

Factors that modify the effect of the putative causal factor(s) under study.

Adverse effect upon bodies of water (lakes, RIVERS, seas, groundwater etc.) caused by CHEMICAL WATER POLLUTANTS.

Quick Search


DeepDyve research library

Relevant Topic

Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Searches Linking to this Article