A case of merkel leptomeningeal evolution after complete remission upon anti-PD-1 treatment.

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Summary of "A case of merkel leptomeningeal evolution after complete remission upon anti-PD-1 treatment."

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Name: European journal of cancer (Oxford, England : 1990)
ISSN: 1879-0852
Pages: 55-57


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Medical and Biotech [MESH] Definitions

A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)

Modified epidermal cells located in the stratum basale. They are found mostly in areas where sensory perception is acute, such as the fingertips. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber. Do not confuse with Merkel's corpuscle which is a combination of a neuron and an epidermal cell.

Therapeutic act or process that initiates a response to a complete or partial remission level.

A species of POLYOMAVIRUS suspected to be the cause of most cases of MERKEL CELL CARCINOMA, a rare but highly lethal form of skin cancer.

The interdisciplinary science that studies evolutionary biology, including the origin and evolution of the major elements required for life, their processing in the interstellar medium and in protostellar systems. This field also includes the study of chemical evolution and the subsequent interactions between evolving biota and planetary evolution as well as the field of biology that deals with the study of extraterrestrial life.

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