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Designing reasonably priced bioactive organic-inorganic hybrid materials featuring osteogenic activity has received a significant interest in the bone tissue engineering field. In this study, eggshell membrane (ESM), which consists mostly of proteins exhibiting fibrous network structure, was utilised innovatively as a template to prepare eggshell membrane/hydroxyapatite (ESM-HA) composites using a versatile biomimetic mineralisation technique. In addition, the surface morphology and composition, hydrophilicity, crystallinity, and thermal stability of both sides of ESM and ESM-HA composites were systematically studied. Results indicated that both sides of ESM exhibited excellent biomimetic mineralisation ability, and the hydrophilicity and thermal stability of ESM were effectively improved by the introduction of HA. Moreover, in vitro experiments on MC3T3-E1 cells revealed that the inner side of the ESM was more beneficial to cell proliferation and adhesion than the outer side. Remarkably, the proliferation, adhesion and spreading, as well as the alkaline phosphatase (ALP) activity and expression of bone-related genes and proteins (runt-related transcription factor 2, ALP, collagen type I, and osteocalcin) on both sides of ESM-HA composites were significantly higher compared to those of the original ESM. These findings suggested that ESM-HA composites obtained using biomimetic mineralisation could be potential new materials for future bone tissue repair.
This article was published in the following journal.
Name: Colloids and surfaces. B, Biointerfaces
Tissue engineering is an appealing research field that involves the replacement and repair of damaged cells and tissues. Scientists and researchers are facing a great challenge to design and develop s...
The electrospinning PAN nanofiber membrane (P-CN) was hydrolysed to convert carboxylic groups as reaction sites and covalently graft chitosan molecule. The chitosan derivatives with quaternary ammoniu...
In past decades, rapid progress in nanoparticle (NP) synthesis and engineering has provided a broad range of nanoscale agents affording both therapeutic and diagnostic functions. More recently, the em...
The use of biomimetic scaffolds for bone tissue engineering has been studied for a long time. Biomimetic scaffolds can assist and accelerate bone regeneration that is similar to that of authentic tiss...
In 1695 the Italian anatomist and physician Lorenzo Bellini published an account of the 'airways' in birds' eggs. Bellini suggested that these structures - that appear as dark channels running between...
The purpose of this study was to evaluate the use of the dietary supplement Natural Eggshell Membrane (NEM) for the treatment of joint and connective tissue discomfort & pain.
The purpose of this study was to evaluate the use of the dietary supplement Natural Eggshell Membrane (NEM) for the treatment of joint and connective tissue discomfort, pain, and flexibili...
This study is intended to evaluate the effect of the dietary supplement NEM® brand eggshell membrane versus placebo in reducing exercise-induced joint pain, stiffness & cartilage turnover...
Evaluation of Marginal Integrity of Hydroxyapatite Nano-Fiber Reinforced Flowable Composite Versus Conventional Resin-Based Flowable Composite in Initially Demineralized Pits and Fissure: A One Year, Randomized Clinical Trial
This study will be conducted to evaluate the Marginal integrity of Hydroxyapatite Nanofiber reinforced flowable composite compared to a conventional resin-based flowable composite during m...
Young children in Ethiopia lack sufficient protein and micronutrients for growth and development. The overall purpose is to assess the effects of promoting egg and eggshell powder consumpt...
Materials fabricated by BIOMIMETICS techniques, i.e., based on natural processes found in biological systems.
A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane.
A perilipin that localizes to LIPID DROPLETS; CYTOPLASM; ENDOSOMES; and PLASMA MEMBRANE, especially in MACROPHAGES. It functions as a transporter of free fatty acids to lipid droplets to promote their biogenesis and growth. It is also required for the transport of the MANNOSE-6-PHOSPHATE RECEPTOR from endosomes to the TRANS-GOLGI NETWORK. Its structure consists of four helix bundles that interact with the hydrophobic lipid droplet surface.
An interdisciplinary field in materials science, ENGINEERING, and BIOLOGY, studying the use of biological principles for synthesis or fabrication of BIOMIMETIC MATERIALS.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
Osteoporosis is a disease in which the bones become extremely porous, are subject to fracture, and heal slowly, occurring especially in women following menopause and often leading to curvature of the spine from vertebral collapse. Follow and track&n...