Development and Validation of the Mucosal Inflammation Non-invasive Index For Pediatric Crohn's Disease.

08:00 EDT 10th April 2019 | BioPortfolio

Summary of "Development and Validation of the Mucosal Inflammation Non-invasive Index For Pediatric Crohn's Disease."

Mucosal healing (MH) has become a goal of therapy for Crohn's disease (CD), but frequent endoscopies are not feasible. We aimed to develop and validate a non-invasive index to assess mucosal inflammation in children with CD.


Journal Details

This article was published in the following journal.

Name: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
ISSN: 1542-7714


DeepDyve research library

PubMed Articles [24401 Associated PubMed Articles listed on BioPortfolio]

Clinical disease activity and endoscopic severity correlate poorly in children newly diagnosed with Crohn's Disease.

/Aims: Treatment goals in Crohn's disease (CD) have evolved to target mucosal healing. There is now a drive to determine if non-invasive measures can adequately identify the attainment and persistence...

Development and Validation of a Simplified Magnetic Resonance Index of Activity for Crohn's disease.

The magnetic resonance index of activity (MARIA) for Crohn's disease (CD) is used to assess the activity of luminal Crohn's disease (CD). However, it has a number of practical limitations. We aimed to...

Mucosal healing and bacterial composition in response to enteral nutrition versus steroid based induction therapy - a randomized prospective clinical trial in children with Crohn's disease.

Exclusive Enteral Nutrition (EEN) is as efficacious as corticosteroids (CS) to induce remission in Crohn's disease (CD), without their adverse effects. EEN seems to be more efficient than steroids to ...

Infliximab Trough Levels Are Associated With Mucosal Healing During Maintenance Treatment With Infliximab in Paediatric Crohn's Disease.

Mucosal healing is an important treatment goal in Crohn's disease. We investigated the association between serum infliximab trough levels and mucosal healing, and the infliximab cut-off levels require...

A Treat to Target Strategy Using Pan-Enteric Capsule Endoscopy in Pediatric Patients With Crohn's Disease.

Pan-enteric capsule endoscopy (PCE) is effective for assessment of small intestinal and colonic Crohn's disease (CD) in pediatric patients. We aimed to determine whether PCE can be used to monitor muc...

Clinical Trials [13614 Associated Clinical Trials listed on BioPortfolio]

FMT in Pediatric Crohn's Disease

The goal of this study is to evaluate the safety of Fecal Microbiota Transplantation (FMT) in children with Crohn's disease who are in remission. Safety will be the primary endpoint and Pe...

The Efficacy of Low Dose Naltrexone Therapy in Children With Crohn's Disease

It is hypothesized that oral naltrexone will improve inflammation of the bowel by increasing endogenous enkephalin levels in subjects with active Crohn's disease. This is especially impor...

RED-FLAGS Index Validation in Crohn's Disease Patients

Observational prospective study to validate a new index for early diagnosis of Crohn's disease (CD)

Lactobacillus GG in Pediatric Ulcerative Colitis (UC)

Abstract: Current evidence suggests that the enteric flora is the primary trigger for chronic mucosal inflammation in the Inflammatory Bowel Diseases (IBD), Crohn's Disease (CD) and Ulcer...

Synbiotic Treatment in Crohn's Disease Patients

The purpose of this study is to determine whether administration of a synbiotic, comprised on inulin and a bifidobacterial probiotic will colonise the gut wall and down-regulate TNF-alpha ...

Medical and Biotech [MESH] Definitions

A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.

Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.

Registered nurses with graduate degrees in nursing who provide care to pediatric patients who are acutely or critically ill.

A humanized monoclonal antibody that binds specifically to TNF-ALPHA and blocks its interaction with endogenous TNF RECEPTORS to modulate INFLAMMATION. It is used in the treatment of RHEUMATOID ARTHRITIS; PSORIATIC ARTHRITIS; CROHN'S DISEASE and ULCERATIVE COLITIS.

A condition characterized by persistent or recurrent labial enlargement, ORAL ULCER, and other orofacial manifestations in the absence of identifiable CROHN DISEASE; or SARCOIDOSIS. There is no consensus on whether orofacial granulomatosis is a distinct clinical disorder or an initial presentation of Crohn disease.

Quick Search


DeepDyve research library

Relevant Topics

Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...

Complementary and Alternative Medicine
Alternative medicine are whole medical systems that did not fit with conventional medicine as they have completely different philosophies and ideas on the causes of disease, methods of diagnosis and approaches to treatment. Although often overlapping, co...

Searches Linking to this Article