Modulation of frailty syndrome by diet: a review of evidence from mouse studies.

08:00 EDT 10th April 2019 | BioPortfolio

Summary of "Modulation of frailty syndrome by diet: a review of evidence from mouse studies."

Frailty is a progressive, aging-related syndrome of unknown etiology characterized by increased susceptibility and decreased resilience to external stressors. Understanding underlying mechanisms and identifying interventions to improve resilience are major challenges in biogerontology. Adequate nutrition is central to organismal health and wellbeing and can be modulated to improve longevity. While there are clear associations between poor nutrition (excess or deficient calorie intake) and frailty in humans, only recently has the link between frailty and nutrition been addressed in experimental model systems in which causality and molecular mechanisms can be explored. Here we review the evidence linking nutrition to the frailty syndrome, including individual aspects such as muscle function, body composition and chronic disease, with a specific focus on mouse models and experimental nutritional interventions including dietary restriction.


Journal Details

This article was published in the following journal.

Name: Mechanisms of ageing and development
ISSN: 1872-6216


DeepDyve research library

PubMed Articles [28377 Associated PubMed Articles listed on BioPortfolio]

Review of Interventions for the Frailty Syndrome and the Role of Metformin as a Potential Pharmacologic Agent for Frailty Prevention.

Frailty is a syndrome of vulnerability and physical decline with aging that increases risk for disability, hospitalizations, and death. To date, interventions for frailty have primarily focused on e...

Nutritional interventions for the treatment of frailty in older adults: a systematic review protocol.

Frailty has been defined as a clinical syndrome of multicausal origin characterized by a reduction of physiologic reserves that increase the vulnerability of an individual to adverse outcomes such as ...

Should we screen for frailty in primary care settings? A fresh perspective on the frailty evidence base: A narrative review.

With older adults living longer, health service providers have increasingly turned their attention towards frailty and its significant consequences for health and well-being. Consequently, frailty scr...

Physical frailty in older men: prospective associations with diet quality and patterns.

increasing numbers of older adults are living with frailty and its adverse consequences. We investigated relationships between diet quality or patterns and incident physical frailty in older British m...

Assessing onset, prevalence and survival in mice using a frailty phenotype.

Little is known whether frailty assessments in mice are capable of distinguishing important characteristics of the frailty syndrome. The goals of this study were to identify the onset and the prevalen...

Clinical Trials [10231 Associated Clinical Trials listed on BioPortfolio]

Study on Cardiovascular Health, Nutrition and Frailty in Older Adults in Spain

The purpose of this study is to examine the association between ideal cardiovascular health, diet and other lifestyles, biological risk factors, either well-established or emergent, and th...

Frailty Assessment in Elderly Patients With Acute Coronary Syndrome

Frailty is known as an independent risk factor for morbidity and mortality in older cardiac patients . It is an important factor on the cardiologist decision between conservative and invas...

Development and Validation of a Preoperative Frailty Index Using Health Administrative Data

The investigators will create a frailty index using health administrative data available for older people having surgery. The index will be based on the Canadian Study of Health and Aging ...

Protein and Exercise to Counteract Frailty in Older Adults

The purpose of this study is to determine the effects of interventions with high-protein diet alone or in combination with resistance training on muscle mechanical function (muscle power a...

Frailty Assessment and Treatment Strategies in the Elderly at Risk of Functional Decline in the Community

This study aims to design a patient -centered program to prevent or delay frailty , functional decline and adverse events, and evaluates the effectiveness of the program with a randomized ...

Medical and Biotech [MESH] Definitions

An approach, process, or methodology which emphasizes credible evidence and the best available scientific knowledge, judiciously integrated to achieve the best possible outcomes in structural design. For example, the design of a new OUTPATIENT CLINIC might incorporate a review of published research on outpatient clinic design, decisions on similar past projects, along with interviews with staff and consumers.

Review of the medical necessity of hospital or other health facility admissions, upon or within a short time following an admission, and periodic review of services provided during the course of treatment.

A diet that contains limited amounts of CARBOHYDRATES. This is in distinction to a regular DIET.

Regular course of eating and drinking adopted by a person or animal. This does not include DIET THERAPY, a specific diet prescribed in the treatment of a disease.

Formal programs for assessing drug prescription against some standard. Drug utilization review may consider clinical appropriateness, cost effectiveness, and, in some cases, outcomes. Review is usually retrospective, but some analysis may be done before drugs are dispensed (as in computer systems which advise physicians when prescriptions are entered). Drug utilization review is mandated for Medicaid programs beginning in 1993.

Quick Search


DeepDyve research library

Relevant Topics

Public Health
Alternative Medicine Cleft Palate Complementary & Alternative Medicine Congenital Diseases Dentistry Ear Nose & Throat Food Safety Geriatrics Healthcare Hearing Medical Devices MRSA Muscular Dyst...

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...

Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Searches Linking to this Article