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The novel HLA-DRB1*04:01:10 allele detected in a Taiwanese individual.

08:00 EDT 13th April 2019 | BioPortfolio

Summary of "The novel HLA-DRB1*04:01:10 allele detected in a Taiwanese individual."

One nucleotide substitution at residue 261 of HLA-DRB1*04:01:01:01 results in a new allele, HLA-DRB1*04:01:10. This article is protected by copyright. All rights reserved.

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Name: HLA
ISSN: 2059-2310
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Medical and Biotech [MESH] Definitions

A subtype of HLA-DRB beta chains that includes over one hundred allele variants. The HLA-DRB1 subtype is associated with several of the HLA-DR SEROLOGICAL SUBTYPES.

An individual having only one allele at a given locus because of the loss of the other allele through a mutation (e.g., CHROMOSOME DELETION).

The asymmetrical segregation of genes during replication which leads to the production of non-reciprocal recombinant strands and the apparent conversion of one allele into another. Thus, e.g., the meiotic products of an Aa individual may be AAAa or aaaA instead of AAaa, i.e., the A allele has been converted into the a allele or vice versa.

Individual components of atoms, usually subatomic; subnuclear particles are usually detected only when the atomic nucleus decays and then only transiently, as most of them are unstable, often yielding pure energy without substance, i.e., radiation.

The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal hemizygosity. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted. When this occurs at a tumor suppressor gene locus where one of the alleles is already abnormal, it can result in neoplastic transformation (CELL TRANSFORMATION, NEOPLASTIC).

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