Zona pellucida blocks adenovirus from entering porcine oocytes.

08:00 EDT 17th March 2019 | BioPortfolio

Summary of "Zona pellucida blocks adenovirus from entering porcine oocytes."

Adenovirus is a kind of non-enveloped,double-stranded DNA virus. As a member of the mammalian adenoviruses of the Adenoviridae family, porcine adenovirus causes gastrointestinal disease in piglets. In this study, the modified adenovirus was manipulated to carry a green fluorescence EGFP marker. The modified adenovirus was added to medium199 for co-incubation or microinjected into the cytoplasm of porcine oocytes. The effect of adenovirus on the first polar body extrusion was not significant during porcine oocyte maturation. Our data demonstrated the zona pellucida plays a vital role in porcine oocytes being resistant to modified adenovirus. Additionally, the results suggested that oocytes protect themselves from nonself substances.


Journal Details

This article was published in the following journal.

Name: Theriogenology
ISSN: 1879-3231
Pages: 22-26


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[This corrects the article DOI: 10.1371/journal.pone.0218963.].

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Medical and Biotech [MESH] Definitions

Membrane glycoproteins that constitute the ZONA PELLUCIDA in mammals and function in the recognition and binding of SPERMATOZOA.

A tough transparent membrane surrounding the OVUM. It is penetrated by the sperm during FERTILIZATION.

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Interactive processes between the oocyte (OVUM) and the sperm (SPERMATOZOA) including sperm adhesion, ACROSOME REACTION, sperm penetration of the ZONA PELLUCIDA, and events leading to FERTILIZATION.

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