Protein fibrillogenesis model tracked by its intrinsic time-resolved emission spectra.

08:00 EDT 15th April 2019 | BioPortfolio

Summary of "Protein fibrillogenesis model tracked by its intrinsic time-resolved emission spectra."

The excited-state kinetics of the fluorescence of tyrosine in a de novo protein fibrillogenesis model was investigated as a potential tool for monitoring protein fibre formation and complexation with glucose (glycation). In stark contrast to insulin the time-resolved emission spectra (TRES) recorded over the period of 700 hours in buffered solutions of the model with and without glucose revealed no apparent changes in Tyr fluorescence responses. This indicates the stability of the model and provides a measurement-supported basis for its use as a reference material in fluorescence studies of protein aggregation.


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This article was published in the following journal.

Name: Methods and applications in fluorescence
ISSN: 2050-6120


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