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A combined experimental-numerical lamellar-scale approach of tensile rupture in arterial medial tissue using X-ray tomography.

08:00 EDT 1st April 2019 | BioPortfolio

Summary of "A combined experimental-numerical lamellar-scale approach of tensile rupture in arterial medial tissue using X-ray tomography."

Aortic dissection represents a serious cardio-vascular disease and life-threatening event. Dissection is a sudden delamination event of the wall, possibly leading to rupture within a few hours. Current knowledge and practical criteria to understand and predict this phenomenon lack reliable models and experimental observations of rupture at the lamellar scale. In an attempt to quantify rupture-related parameters, the present study proposes an analytical model that reproduces a uniaxial test on medial arterial samples observed under X-ray tomography. This model is composed of several layers that represent the media of the aortic wall, each having proper elastic and damage properties. Finite element models were created to validate the analytical model using user-defined parameters. Once the model was validated, an inverse analysis was used to fit the model parameters to experimental curves of uniaxial tests from a published study. Because this analytical model did not consider delamination strength between layers, a finite element model that included this phenomenon was also developed to investigate the influence of the delamination on the stress-strain curve through a sensitivity analysis. It was shown that shear delamination strength between layers, i.e. mode II separation, is essential in the rupture process observed experimentally.

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This article was published in the following journal.

Name: Journal of the mechanical behavior of biomedical materials
ISSN: 1878-0180
Pages: 116-123

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