Synaptogenic pathways.

08:00 EDT 12th April 2019 | BioPortfolio

Summary of "Synaptogenic pathways."

During synaptogenesis, presynaptic and postsynaptic assembly are driven by diverse molecular mechanisms, mediated by intrinsic as well as extrinsic factors. How these processes are initiated and coordinated are open questions. Synapse specificity, or synaptic partner selection, is widely understood to be determined by the trans-synaptic binding of cell adhesion molecules. However, in vivo evidence that cell adhesion molecules subsequently function to initiate synapse assembly, as initially proposed, is lacking. Here, we present a summary of our current understanding of synaptogenic pathways that mediate presynaptic and postsynaptic assembly and the coordination of these processes.


Journal Details

This article was published in the following journal.

Name: Current opinion in neurobiology
ISSN: 1873-6882
Pages: 156-162


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