The effect of treatment response on endothelial function and arterial stiffness in depression. A prospective study.

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Summary of "The effect of treatment response on endothelial function and arterial stiffness in depression. A prospective study."

Major depression is associated with endothelial dysfunction and arterial stiffening, which may mediate development of hypertension and increased cardiovascular risk. The effect of response to antidepressant treatment on these vascular parameters has not been elucidated.


Journal Details

This article was published in the following journal.

Name: Journal of affective disorders
ISSN: 1573-2517
Pages: 190-200


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Medical and Biotech [MESH] Definitions

Loss of vascular ELASTICITY due to factors such as AGING; and ARTERIOSCLEROSIS. Increased arterial stiffness is one of the RISK FACTORS for many CARDIOVASCULAR DISEASES.

Tendency toward a lessened strength of response due to practice or activity. It is independent of the effect of reward and is a direct function of time interval since the last response and the number of preceding responses.

An MAO inhibitor that is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in the treatment of panic disorder and the phobic disorders. (From AMA, Drug Evaluations Annual, 1994, p311)

The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.

An adverse effect occurring with a medical treatment that is not attributable to the actions of the treatment.

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