Advertisement

Topics

Effects of early life adversity and FKBP5 genotype on hippocampal subfields volume in major depression.

08:00 EDT 9th April 2019 | BioPortfolio

Summary of "Effects of early life adversity and FKBP5 genotype on hippocampal subfields volume in major depression."

Smaller hippocampus volume represents a consistent finding in major depression (MDD). Hippocampal neuroplasticity due to chronic stress might have differential effect on hippocampal subfields. We investigated the effects of the rs1360780 polymorphism of the hypothalamic-pituitary-axis related gene FKBP5 in combination with early life stress (ELA) on the structure of hippocampal subfields in MDD.

Affiliation

Journal Details

This article was published in the following journal.

Name: Journal of affective disorders
ISSN: 1573-2517
Pages: 152-159

Links

DeepDyve research library

PubMed Articles [26142 Associated PubMed Articles listed on BioPortfolio]

Early life adversity blunts responses to pioglitazone in depressed, overweight adults.

Early life adversity is associated with both metabolic impairment and depression in adulthood, as well as with poorer responses to antidepressant medications. It is not yet known whether individual di...

The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation.

To examine variation in child DNA methylation to assess its potential as a pathway for effects of childhood social adversity on health across the life course.

Posttraumatic stress disorder, social anxiety disorder and childhood trauma: Differences in hippocampal subfield volume.

Volume-based hippocampal findings in Social Anxiety Disorder (SAD) and Posttraumatic Stress Disorder (PTSD) have been inconsistent, with very little investigation of hippocampal subfields. We assessed...

Differences in functional connectivity along the anterior-posterior axis of human hippocampal subfields.

There is a paucity of information about how human hippocampal subfields are functionally connected to each other and to neighbouring extra-hippocampal cortices. In particular, little is known about wh...

Regionally specific volume deficits along the hippocampal long axis in early and chronic psychosis.

Previous studies in psychosis patients have shown hippocampal volume deficits across anterior and posterior regions or across subfields, but subfield specific changes in volume along the hippocampal l...

Clinical Trials [9474 Associated Clinical Trials listed on BioPortfolio]

Tailored Inhibitory Control Training to Reverse EA-linked Deficits in Mid-life

Insufficient inhibitory control is one pathway through which early adversity is related to a range of problems including excessive alcohol use, tobacco use, and unhealthy eating. The propo...

Depression, Adversity, and Stress Hormones (DASH) Study

The stress-related hormone cortisol has been studied in depression for decades. However, relatively little is known about the role of cortisol in psychological features of depression. Basi...

Hippocampal Plasticity of Young Adults With Childhood Adversity After MBSR

This study investigates the clinical and neural effects of MBSR for young adults with childhood adversity. The investigators will recruit 60 young adults (19-35 years old) who will be rand...

Hippocampal Complex Volume and Memory Dysfunction in Cushing's Syndrome

OBJECTIVES: I. Evaluate whether chronic hypercortisolemia is specifically toxic to hippocampal cells and causes structural reduction of hippocampal volume in patients with Cushing's syndr...

Exploring the Effects of Corticosteroids on the Human Hippocampus

Chronic corticosteroid (CS) exposure is associated with changes in memory and the hippocampus in both humans and in animal models. The hippocampus has a high concentration of glucocorticoi...

Medical and Biotech [MESH] Definitions

The human ability to adapt in the face of tragedy, trauma, adversity, hardship, and ongoing significant life stressors.

The experimental study of the relationship between the genotype of an organism and its behavior. The scope includes the effects of genes on simple sensory processes to complex organization of the nervous system.

A curved elevation of gray matter extending the entire length of the floor of the temporal horn of the lateral ventricle. The hippocampus, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.

The use of sophisticated methods and equipment to treat cardiopulmonary arrest. Advanced Cardiac Life Support (ACLS) includes the use of specialized equipment to maintain the airway, early defibrillation and pharmacological therapy.

The study of early forms of life through fossil remains.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topics

Depression
Depression is a serious mental health condition, where sad feelings carry on for weeks or months and interfere with your life. The symptoms include feeling unhappy most of the time (but may feel a little better in the evenings), loosing interest in lif...

Stress
Stress is caused by your perception of situations around you and then the reaction of your body to them. The automatic stress response to unexpected events is known as 'fight or flight'. Discovered by Walter Cannon in 1932, it is the release of h...


Searches Linking to this Article