Binary-ternary Cd(II)-(hydroxycarboxylic acid)-(aromatic chelator) systems exhibit in vitro cytotoxic selectivity in a tissue-specific manner.

07:00 EST 23rd February 2019 | BioPortfolio

Summary of "Binary-ternary Cd(II)-(hydroxycarboxylic acid)-(aromatic chelator) systems exhibit in vitro cytotoxic selectivity in a tissue-specific manner."

Cadmium is a metallotoxin, amply encountered in the environment and derived through physical and anthropogenic activities. Its entry in various organisms leads through water and the food chain to humans, thereby inducing a plethora of pathophysiologies. Delineation of the interactive role of cadmium with physiological and physiologically relevant substrates, requires well-defined forms of cadmium arising from such interactions along with the ensuing chemical reactivity amounting to toxic manifestations and health aberrations. To implement such efforts, low molecular mass substrate metal ion binders are needed, forming species with enhanced solubility and bioavailability. To that end, α-hydroxy isobutyric acid (HIBAH) was used in pH-specific synthetic efforts involving bulky aromatic chelators 2,2'-bipyridine (2,2'-bipy) and 1,10-phenanthroline (phen), thus leading to new crystalline materials [Cd(CHO)](1), [Cd(CHO)(HO)](2), [{Cd(CHO)(CHN)(HO)}(NO)]·nHO(3), and [{Cd(CHO)(CHN)(HO)}(NO)]·2nHO(4), which were physicochemically characterized (elemental analysis, FT-IR, NMR, ESI-MS, and X-ray crystallography) in the solid state and solution. Their physicochemical characteristics led to their employment in tissue-specific biological toxicity studies in three different cell lines. Their toxicity profile (cell viability, morphology, chemotacticity) was correlated through genetic biomarkers to apoptotic-necrotic processes, thereby shedding light on cadmium cellular toxicity processes. Finally, the cytoprotective action of specific chelators was examined, lending credence to the notion that appropriately structured chelators and antioxidants may be used as effective deterrent to cadmium toxicity. Collectively, structure-specificity linked to tissue-specific toxicity profiling in well-defined binary-ternary Cd(II)-HIBAH systems exemplifies that metal ion's aberrant interactions in the cellular milieu, meriting further probing into the development of efficient chelators in cadmium detoxification.


Journal Details

This article was published in the following journal.

Name: Journal of inorganic biochemistry
ISSN: 1873-3344
Pages: 201-215


DeepDyve research library

PubMed Articles [15939 Associated PubMed Articles listed on BioPortfolio]

Formation and stability of the mixed-chelator complexes of Sr, Mg, Ca, Ba, and Y in solution with bio-relevant chelators.

The formation and equilibria of Sr, Mg, Ca, Ba, and Y (M) complexes with a mixed-chelator comprising two biodegradable chelators (GLDA, L, 2-[bis(carboxymethyl)amino] pentanedioic acid; HIDS, L, 2-(1,...

Effect of organic acids on molecular mobility, physical stability and dissolution of ternary ketoconazole spray dried dispersions.

In an earlier investigation, ketoconazole (KTZ) - organic acid coamorphous systems were prepared, wherein, in the solid-state, there was ionic and/or hydrogen bonding interactions between the drug and...

Comparison of Approaches for Measuring and Predicting the Viscosity of Ternary Component Aerosol Particles.

Measurements of the water activity-dependent viscosity of aerosol particles from two techniques are compared, specifically from the coalescence of two droplets in a Holographic Optical Tweezers (HOT) ...

Definition of frame-invariant thermodiffusion and Soret coefficients for ternary mixtures.

The definitions of thermodiffusion and Soret coefficients for a binary mixture include a concentration prefactor x(1 - x), when mole fraction x is used, or w(1 - w), when mass fraction w is used. In t...

On-Axis Alignment of Protein Nanocage Assemblies from 2D to 3D through the Aromatic Stacking Interactions of Amino Acid Residues.

Aromatic-aromatic interactions between natural aromatic amino acids Phe, Tyr, and Trp play crucial roles in protein-protein recognition and protein folding. However, the function of such interactions ...

Clinical Trials [4500 Associated Clinical Trials listed on BioPortfolio]

Determining Total Aromatic Amino Acid Requirements in Pregnant Women

Phenylalanine and tyrosine are aromatic amino acids that people need to obtain in their diets. Amino acids are the building blocks for protein, are are therefore required to form tissues i...

Aromatic Amino Acid Metabolism in the Pathogenesis of Kwashiorkor

This research may explain whether a shortage of three special compounds called aromatic amino acids is responsible for the severe illness and high death rate of children with the kwashiork...

A Clinical Trial for Treatment of Aromatic L-amino Acid Decarboxylase (AADC) Deficiency Using AAV2-hAADC - An Expansion

This clinical trial expansion is to offer patients, who are not enrolled into the Phase I/II trial, a chance of treatment, to extend the experience in this gene therapy, and to increase th...

Treatment of Acute Pharyngo-Tonsillitis With Essential Oils of Aromatic Plants

This randomized, double blind, parallel group study, compared the efficacy of spray containing aromatic essential oils of some herbal plants, against placebo in the treatment of patients w...

Performance of Scoring Systems in Chinese Patients With Primary Biliary Cholangitis (PBC) on Ursodeoxycholic Acid

Several risk assessment scoring systems have been proposed to assess the therapeutic response and predict long term prognosis in ursodeoxycholic acid (UDCA)-treated primary biliary cholang...

Medical and Biotech [MESH] Definitions

An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.

Compounds and drugs that block or inhibit the enzymatic action of AROMATIC AMINO ACID DECARBOXYLASES. Pharmaceutical agents in this category are used in conjunction with LEVODOPA in order to slow its metabolism.

The study of systems which respond disproportionately (nonlinearly) to initial conditions or perturbing stimuli. Nonlinear systems may exhibit "chaos" which is classically characterized as sensitive dependence on initial conditions. Chaotic systems, while distinguished from more ordered periodic systems, are not random. When their behavior over time is appropriately displayed (in "phase space"), constraints are evident which are described by "strange attractors". Phase space representations of chaotic systems, or strange attractors, usually reveal fractal (FRACTALS) self-similarity across time scales. Natural, including biological, systems often display nonlinear dynamics and chaos.

An enzyme group with broad specificity. The enzymes decarboxylate a range of aromatic amino acids including dihydroxyphenylalanine (DOPA DECARBOXYLASE), tryptophan, and hydroxytryptophan. EC

A cyclohexadiene carboxylic acid derived from SHIKIMIC ACID and a precursor for the biosynthesis of UBIQUINONE and the AROMATIC AMINO ACIDS.

Quick Search


DeepDyve research library

Relevant Topic

Food is any substance consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism ...

Searches Linking to this Article