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Metal ions or nanoparticles are believed to be promising additives in developing antibacterial biomaterials, owing to possessing favorable bactericidal effects against antibiotic-resistant bacteria. However, the immunomodulatory antibacterial activity of metal ions has seldom been reported. Herein, a porous microstructure designed to trap methicillin-resistant Staphylococcus aureus (MRSA) is fabricated on polyetheretherketone biomaterial surface through sulfonation (SPEEK), following which copper (Cu) nanoparticles, which can kill the trapped MRSA, are immobilized on SPEEK surface using a customized magnetron sputtering technique. In vitro antibacterial and immunological experiments indicate that the Cu-incorporated SPEEK can exert a desirable bactericidal effect against MRSA through the combination of "trap killing" and "contact killing" actions; meanwhile, macrophages cultured on the Cu-incorporated SPEEK can be activated and polarized to a pro-inflammatory phenotype along with improved phagocytic ability on the MRSA. Further in vivo implant-associated infection models evidence the superior antibacterial activity of the Cu-incorporated SPEEK. These results demonstrate multimodal antibacterial actions of the Cu-incorporated SPEEK, which is capable of imposing direct antibacterial and indirect immunomodulatory antibacterial effects simultaneously, in order to prevent and cure MRSA infection. It is believed that this study may shed light on developing novel biomaterial implants that combine antibacterial and immunomodulatory functions.
This article was published in the following journal.
The aim of this study was to characterize and compare the behavior of human osteoblasts and human gingival fibroblasts in contact with polyetheretherketone (PEEK), zirconia, and titanium implant surfa...
Bacterial adherence and biofilm formation on the surface of biomaterials can often lead to implant-related infections, which may vary depending on the species of microorganisms, type of biomaterial us...
Rapid implant vascularization is a prerequisite for successful biomaterial engraftment. Vitronectin (VN) is a matricellular glycoprotein well known for its capability to interact with growth factors, ...
Polyetheretherketone (PEEK) is considered to be a prime candidate with the potential to replace biomedical metallic materials as an orthopedic and dental implant on account of its elastic modulus simi...
The purpose of this study was to compare the fracture resistances and the fracture types of titanium, zirconia, and ceramic-reinforced polyetheretherketone (PEEK) implant abutments supporting CAD/CAM ...
Angiogenesis is inherently associated to bone formation and healing. During implant osseointegration, a successive and successful angiogenic processes has to occur to promote bone formatio...
Soft tissue attachment to the implant surface serves as a biological seal preventing the development of inflammatory periimplant diseases (i.e. peri-implant mucositis and peri-implantitis)...
Aim: The aim of this study to Assess the healing process of the immediate implant loading with two different provisional techniques (direct and indirect). Materials and methods: 20...
This study was conducted to compare implant stability of Hiossen ET III implants with its new hydrophilic surface (NH) and Hiossen ET III implants with the SA surface.
This post-market study is to show that dental implants with a SLActive® surface (SLActive® implants) show non-inferior clinical performance compared to dental implants with a SLA® surfa...
Insertion of an implant into the bone of the mandible or maxilla. The implant has an exposed head which protrudes through the mucosa and is a prosthodontic abutment.
Techniques utilizing cells that express RECOMBINANT FUSION PROTEINS engineered to translocate through the CELL MEMBRANE and remain attached to the outside of the cell.
Endosseous dental implantation where implants are fitted with an abutment or where an implant with a transmucosal coronal portion is used immediately (within 1 week) after the initial extraction. Conventionally, the implantation is performed in two stages with more than two months in between the stages.
The plan and delineation of DENTAL IMPLANT fitting with DENTAL ABUTMENT.
Guided BONE TRANSPLANTATION of the MAXILLARY SINUS surface with a BONE SUBSTITUTE grafting. It increases the bone volume at the site of the DENTAL IMPLANT and helps stabilize it.
A biomaterial is defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic proc...
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