Agonist-evoked endothelial Ca signalling microdomains.

08:00 EDT 12th April 2019 | BioPortfolio

Summary of "Agonist-evoked endothelial Ca signalling microdomains."

Localized, oscillating Ca signals have been identified in discrete microdomains of vascular endothelial cells. At myoendothelial contacts (between endothelial and smooth muscle cells), both endothelial Ca pulsars (IP-mediated release of intracellular Ca) and Ca sparklets (extracellular Ca entry via TRP channels) contribute to endothelium-dependent hyperpolarization of smooth muscle, vasodilation, and feedback control of vasoconstriction. Ca sparklets occurring at close-contact domains between endothelial cells are possibly involved in conducted hyperpolarization and spreading vasodilation in arterial networks. This review summarizes these Ca signalling phenomena, examines the proposed mechanisms leading to their generation by G-protein-coupled receptor agonists, and explores the proposed physiological roles of these localized and specialized Ca signals.


Journal Details

This article was published in the following journal.

Name: Current opinion in pharmacology
ISSN: 1471-4973
Pages: 8-15


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