Regular swimming exercise attenuated neuroma pain in rats: involvement of leptin and adiponectin.

08:00 EDT 12th April 2019 | BioPortfolio

Summary of "Regular swimming exercise attenuated neuroma pain in rats: involvement of leptin and adiponectin."

Accumulating evidence demonstrates the beneficial effects of physical exercise on pain conditions, however, the underlying mechanisms have not been thoroughly understood. The purpose of the present study was to investigate the effects of regular swimming exercise on neuroma pain and the possible roles of adipokines (leptin and adiponectin) in the pain behaviors modulated by exercise. The results showed that five weeks of regular swimming exercise relieved pain behaviors in a rat model of neuroma pain and normalized the dysregulation of circulating leptin and adiponectin in plasma induced by nerve injury. Moreover, regular swimming exercise reversed the altered expressions of leptin receptor and adiponectin receptor 1 in neuroma. In addition, administration of exogenous leptin to the neuroma site dampened the effects of regular swimming exercise on neuroma pain and adiponectin administration alleviated the neuroma pain in the non-exercised neuroma rats. These findings indicate that leptin and adiponectin might be involved in mediating the beneficial effects of exercise on neuroma pain. Perspective: Identifying which endogenous processes are activated by specific exercise regimes would likely reveal novel therapeutic targets for treatment of neuropathic pain. The current study suggests that adipokines might be involved in pain behaviors modulated by exercise, thus presents them as potential targets for pain management.


Journal Details

This article was published in the following journal.

Name: The journal of pain : official journal of the American Pain Society
ISSN: 1528-8447


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Medical and Biotech [MESH] Definitions

Excavations or containment structures filled with water and used for swimming.

The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.

A moderate-growing, photochromogenic species found in aquariums, diseased fish, and swimming pools. It is the cause of cutaneous lesions and granulomas (swimming pool granuloma) in humans. (Dorland, 28th ed)

Controlled physical activity, more strenuous than at rest, which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used. The intensity of exercise is often graded, using criteria such as rate of work done, oxygen consumption, and heart rate.

An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively.

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