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Eltrombopag Promotes DNA Repair in Human Hematopoietic Stem and Progenitor Cells.

08:00 EDT 12th April 2019 | BioPortfolio

Summary of "Eltrombopag Promotes DNA Repair in Human Hematopoietic Stem and Progenitor Cells."

A causal link between hematopoietic stem/progenitor cell (HSPC) dysfunction and DNA damage accrual has been proposed. Clinically relevant strategies to maintain genome integrity in these cells are needed. Here we report that eltrombopag, a small molecule agonist of the thrombopoietin (TPO) receptor used in the clinic, promotes DNA double strand break (DSB) repair in human HSPCs. We demonstrate that eltrombopag specifically activates the classical non-homologous end joining (C-NHEJ) DNA repair mechanism, a pathway known to support genome integrity. Eltrombopag-mediated DNA repair results in enhanced genome stability, survival and function of primary human HSPCs, as demonstrated in karyotyping analyses, colony forming unit assays and after transplantation in immunodeficient NSG mice. Eltrombopag may offer a new therapeutic modality to protect human HSPCs against genome insults.

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This article was published in the following journal.

Name: Experimental hematology
ISSN: 1873-2399
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