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For administration of therapeutic agents, the oral route is favored since it is comfortable to patients and also requires a reduced cost. Recently, a considerable amount of work has been reported on carboxymethyl cellulose as oral delivery systems. In contrast to all other polysaccharides having a profile in a pharmacopeia, carboxymethyl cellulose has a hydrophilic character because of its carboxylate groups. These carboxylate groups are responsible for properties such as in situ gellation, bioadhesion, sensitivity to environmental stimuli and controlled drug release. Most of these properties can even be further improved via chemical modifications. In this review, an overview of the carboxymethyl cellulose advantages for oral delivery systems is presented.
This article was published in the following journal.
Name: International journal of biological macromolecules
Two types of core/shell fibers based on carboxymethyl chitosan and Sodium carboxymethyl cellulose with self-assembled liposome for buccal delivery of carvedilol across TR146 cell culture and porcine buccal mucosa.
Two novel core-shell fibers which could self-assemble liposome were fabricated based on bioadhesive polymer carboxymethyl chitosan (CMCS) and Sodium carboxymethyl cellulose (CMC-Na), separately. The s...
Two-level systems for oral delivery of therapeutic peptides were developed; the carriers consist of CaCO3 cores included into alginate granules. Such systems were first used for the delivery of low mo...
We report hybrid gels based on a high-amylose starch and microcrystalline cellulose with demonstrated properties for gastric-floating drug delivery purposes. The starch/cellulose gels were prepared by...
Lipid-based drug delivery systems has become a popular choice for oral delivery of lipophilic drugs with dissolution rate limited oral absorption. Lipids are known to enhance oral bioavailability of p...
Carboxymethyl konjac glucomannan (CMKGM) shows potential in the construction of colon-targeted delivery systems through electrostatic interaction-based techniques. Its coacervation with chitosan (CHI)...
Single-center, randomized, placebo-controlled study to investigate the effect of Resveratrol plus Carboxymethyl-β-Glucan, two sprays (100µL/spray) for nostril three times/day for 4 weeks...
This is a Phase 3, multi-center, randomized, placebo-controlled trial to determine the effectiveness and safety of the 6% cellulose sulfate (CS) vaginal gel for the prevention of HIV infec...
This study aims to investigate dose based oxygen delivery vs. continuous flow of oxygen during simulated altitude conditions as would be experienced after a loss of pressure during commerc...
In post-dilution haemodiafiltration only synthetic membranes have been used to date. The allergy problems described with these membranes require the development of other membranes capable...
The study is a 3-year, randomized trial to compare ART delivery through two different models: a) ART delivered through health facilities by clinically qualified staff and b) home-based car...
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Portable or implantable devices for infusion of insulin. Includes open-loop systems which may be patient-operated or controlled by a pre-set program and are designed for constant delivery of small quantities of insulin, increased during food ingestion, and closed-loop systems which deliver quantities of insulin automatically based on an electronic glucose sensor.
SMOKING vapors produced from ELECTRONIC NICOTINE DELIVERY SYSTEMS.
A type of ion exchange chromatography using diethylaminoethyl cellulose (DEAE-CELLULOSE) as a positively charged resin. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Implanted fluid propulsion systems with self-contained power source for providing long-term controlled-rate delivery of drugs such as chemotherapeutic agents or analgesics. Delivery rate may be externally controlled or osmotically or peristatically controlled with the aid of transcutaneous monitoring.
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...