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Paternal inheritance of diet induced metabolic traits correlates with germline regulation of diet induced coding gene expression.

08:00 EDT 12th April 2019 | BioPortfolio

Summary of "Paternal inheritance of diet induced metabolic traits correlates with germline regulation of diet induced coding gene expression."

Inheritance of induced traits through the germline is poorly understood and controversial. The ideal evidence correlating induced and inherited traits with germline gene expression remains largely obscure. Using a Drosophila coding transcriptome level model of paternal high sugar diet induced alterations in triglyceride levels across generations, in conjunction with pre-existing data, we show here highly significant overlap of differentially expressed genes between the ancestral generation, the resulting sperm and embryos, and the future generation individuals. Further, gene ontology and literature-wide overrepresentation analysis reveal association of lipid and carbohydrate metabolism, and immune response, besides others, with differentially expressed genes in the above samples. Analysis of available mouse data on inheritance of diet induced metabolic traits also revealed a similar correlation. Our results support a causal role of sperm borne mRNAs in inheritance of acquired characteristics, consistent with the evidence that these mRNAs are delivered to the oocyte and influence embryonic development.

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This article was published in the following journal.

Name: Genomics
ISSN: 1089-8646
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Medical and Biotech [MESH] Definitions

A form of inheritance where the traits of the offspring are paternal in origin due to the expression of extra-nuclear genetic material such as MITOCHONDRIAL DNA or Y chromosome genes. CENTRIOLES are also paternally inherited.

A diet that contains limited amounts of fat with less than 30% of calories from all fats and less than 10% from saturated fat. Such a diet is used in control of HYPERLIPIDEMIAS. (From Bondy et al, Metabolic Control and Disease, 8th ed, pp468-70; Dorland, 27th ed)

The different ways GENES and their ALLELES interact during the transmission of genetic traits that effect the outcome of GENE EXPRESSION.

Transmission of genetic characters, qualities, and traits, solely from maternal extra-nuclear elements such as MITOCHONDRIAL DNA or MATERNAL MESSENGER RNA.

A diet that contains limited amounts of CARBOHYDRATES. This is in distinction to a regular DIET.

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