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Uterine Epithelial Development and EZH2: It's Important for More than Just Cancer.

08:00 EDT 12th April 2019 | BioPortfolio

Summary of "Uterine Epithelial Development and EZH2: It's Important for More than Just Cancer."

This commentary highlights the article by Fang et al that describes the role of EZH2 in endometrial development.

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Journal Details

This article was published in the following journal.

Name: The American journal of pathology
ISSN: 1525-2191
Pages:

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PubMed Articles [17661 Associated PubMed Articles listed on BioPortfolio]

EZH2 Is Required for Uterine Epithelial Integrity.

Normal proliferation and differentiation of uterine epithelial cells are critical for uterine development and function. EZH2, a core component of Polycomb Repressive Complexes 2, possesses histone met...

Effect of EZH2 knockdown on preimplantation development of porcine parthenogenetic embryos.

The EZH2 protein endows the polycomb repressive complex 2 (PRC2) with histone lysine methyltransferase activity that is associated with transcriptional repression. Recent investigations have documente...

Upregulation of long noncoding RNA TUG1 by EGR1 promotes adenomyotic epithelial cell migration and invasion through recruiting EZH2 and suppressing TIMP2.

Emerging studies showed that lncRNA TUG1 plays important roles in diverse biological processes. However, there is no previously published research reporting the regulatory role of lncRNAs in the progr...

The ezh2(sa1199) mutant zebrafish display no distinct phenotype.

Polycomb group (PcG) proteins are essential regulators of epigenetic gene silencing and development. The PcG protein enhancer of zeste homolog 2 (Ezh2) is a key component of the Polycomb Repressive Co...

The Attenuation of Trophoblast Invasion Caused by the Downregulation of EZH2 Is Involved in the Pathogenesis of Human Recurrent Miscarriage.

Recurrent miscarriage (RM) is currently defined as two or more losses of a clinically established intrauterine pregnancy. Despite years of research, RM continues to be a clinically frustrating challen...

Clinical Trials [4921 Associated Clinical Trials listed on BioPortfolio]

The Influence of Endometrial Suturing on the Risk of Uterine Scar Defect

Caesarean section (CS) is the commonest major operation performed on women worldwide with progressively rising incidence. Consequently, long-term adverse sequelae due to uterine scar defec...

Vorinostat (SAHA) in Uterine Sarcoma

Uterine sarcomas are rare tumors with a poor prognosis. The main purpose of this phase II proof-of-principle- pilot study is to test the efficacy of the hydroxamic acid-based Histone deac...

Analysis and Optimization of Predictive and Therapeutic Models in Uterine Neoplasms

Evaluation of clinical, therapeutic and prognostic relevance of new experimental results as well as optimization of therapeutic models and development of a new algorithm for therapeutic pl...

Pilot Study of Electronic Uterine Contraction Inhibitor

The objective is to test a novel paradigm for the inhibition of human preterm uterine contractions. The study hypothesis is that human preterm contractions can be safely inhibited with a ...

Does Preventive Uterine Artery Occlusion During Laparoscopic Myomectomy Impact on Ovarian Reserve Markers?

Hysterectomy is an effective treatment used as a first-line approach for uterine myomas. Several others alternatives to hysterectomy have been developed in recent years for women wishing t...

Medical and Biotech [MESH] Definitions

Abnormal development of immature squamous EPITHELIAL CELLS of the UTERINE CERVIX, a term used to describe premalignant cytological changes in the cervical EPITHELIUM. These atypical cells do not penetrate the epithelial BASEMENT MEMBRANE.

Loss or destruction of the epithelial lining of the UTERINE CERVIX.

A protein fraction of pregnant uterine fluid which can induce and regulate blastocystic development. Blastokinin is thought to be similar or identical to uteroglobin. Presence in uterine fluid regulated by progesterone.

Inflation of a balloon catheter within the uterine cavity to control UTERINE HEMORRHAGE.

Phenotypic changes of EPITHELIAL CELLS to MESENCHYME type, which increase cell mobility critical in many developmental processes such as NEURAL TUBE development. NEOPLASM METASTASIS and DISEASE PROGRESSION may also induce this transition.

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