Chemical modulation of alternative splicing for molecular target identification by potential genetic control in agrochemical research.

08:00 EDT 15th April 2019 | BioPortfolio

Summary of "Chemical modulation of alternative splicing for molecular target identification by potential genetic control in agrochemical research."

Alternative splicing (AS), the process of removing introns from pre-mRNA and the re-arrangement of exons to produce several types of mature transcripts, is a remarkable step preceding protein synthesis. In particular, it has now been conclusively shown that up to ~95% of genes are alternatively spliced to generate a complex and diverse proteome in eukaryotic organisms. Consequently, AS is one of the determinants of the functional repertoire of cells. Many studies have revealed that AS in plants can be regulated by cell type, developmental stage, environmental stress, and the circadian clock. Moreover, increasing amounts of evidence reveal that chemical compounds can affect various steps during splicing to induce major effects on plant physiology. Hence, the chemical modulation of AS can serve as good strategy for molecular target identification in attempts to potentially control plant genetics. However, the kind of mechanism involved in the chemical modulation of AS that can be used in agrochemical research remains largely unknown. This review introduces recent studies describing the specific roles AS plays in plant adaptation to environmental stressors and in the regulation of development. We also discuss recent advances of small molecules that induce alterations of AS and the possibilities of using this strategy in agrochemical target identification, which gives a new direction for the potential genetic control in agrochemical research.


Journal Details

This article was published in the following journal.

Name: Journal of agricultural and food chemistry
ISSN: 1520-5118


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