Cryopreserved Umbilical Cord Allograft for Root Coverage of Gingival Recession Defects: A Case Series.

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Summary of "Cryopreserved Umbilical Cord Allograft for Root Coverage of Gingival Recession Defects: A Case Series."

Gingival recession is a component of periodontal disease that leads to exposure of the root surface, root hypersensitivity, and esthetic concerns. Treatment of these cases is typically performed with autologous grafts harvested from the palate. However, this is associated with a second surgical site that increases surgical time and patient morbidity. A potential alternative is the use of cryopreserved umbilical-cord allografts, which are known to contain anti-inflammatory properties and have been used clinically by numerous medical specialties. In this observational series, three patients with gingival recession (average gingival margin [GM]: 3.16 ± 1.13 mm) showing Miller Class I to III gingival recession were treated with cryopreserved umbilical-cord allografts. Ten days after the root coverage procedure, all patients reported no pain or discomfort, and only normal, mild swelling was observed. After 3 months, the gingival tissue was completely healed and matched the color and texture of the patient's surrounding tissue. At 1 year after surgery, patients exhibited 100% root coverage at 33 of 38 treated sites (average
0.18 ± 0.51 mm), as well as an increase in band of attached gingiva. The encouraging safety and effectiveness of this report warrant further investigation of using cryopreserved umbilical cord allografts for periodontal root coverage.


Journal Details

This article was published in the following journal.

Name: The International journal of periodontics & restorative dentistry
ISSN: 1945-3388
Pages: 391-397


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Medical and Biotech [MESH] Definitions

Exposure of the root surface when the edge of the gum (GINGIVA) moves apically away from the crown of the tooth. This is common with advancing age, vigorous tooth brushing, diseases, or tissue loss of the gingiva, the PERIODONTAL LIGAMENT and the supporting bone (ALVEOLAR PROCESS).

Venous vessels in the umbilical cord. They carry oxygenated, nutrient-rich blood from the mother to the FETUS via the PLACENTA. In humans, there is normally one umbilical vein.

Specialized arterial vessels in the umbilical cord. They carry waste and deoxygenated blood from the FETUS to the mother via the PLACENTA. In humans, there are usually two umbilical arteries but sometimes one.

Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.

Techniques used to expose dental surface below the gingival margin in order to obtain better dental impression during periodental and peri-implant applications. The retraction of the gingival tissue can be achieved surgically (e.g., laser gingivectomy and rotary curettage) or chemically with a retraction cord.

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