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A Ag/P-stereogenic phosphine-complex-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with electron-deficient olefins is reported. In this reaction, highly functionalized pyrrolines with a spiro-quaternary stereogenic center were obtained in good yields (up to 99%) with excellent levels of diastereo- (up to >20:1 dr) and enantioselectivities (up to >99% ee). The chirality of adducts was controlled predominantly by the P-stereogenic phosphines.
This article was published in the following journal.
Name: Organic letters
The synthesis of chiral fluorine-containing motifs, especially chiral fluorine molecules with two contiguous stereogenic centers have been gaining current interest in research due to the limited numbe...
An efficient catalytic asymmetric 1,3-dipolar cycloaddition of N-benzylidineiminoglycinate derived azomethine ylides to β-silylmethylene malonates catalysed by a Ag(I)-Fesulphos complex has been deve...
A highly modular, diastereoselective one-pot-synthesis of 1,3-diamines with three contiguous stereogenic centers is reported. Our method provides a fast and efficient access to 1,2-anti-2,3-anti-1,3-d...
Development of a general catalytic and highly efficient method utilizing readily available precursors for the regio- and stereoselective construction of bioactive natural-product-inspired spiro archit...
Cp*Cobalt(III)-catalyzed enantioselective C-H amidation of ferrocenes using monoprotected amino acids (MPAAs) as chiral ligands was developed. The reaction was performed under mild conditions in high ...
Optically Pumped 4He Magnetometers operability for cerebral and cardiac magnetic fields measurement.
This is a research study because it is commonly observed that sleep in its quantity and quality is influenced by the type of mattress used at night. A recent study in patients with back pa...
The anti-factor Xa (anti-Xa) assay is a functional assay that facilitates the measurement of antithrombin (AT)-catalyzed inhibition of factor Xa by unfractionated heparin (UFH) and direct ...
Acute kidney injury is a common complication of severe Plasmodium knowlesi malaria, and an important contributor to mortality. The exact pathogenic mechanisms of AKI in knowlesi malaria a...
Aluminum phosphide poisoning (ALP) is a global public health problem, and self-poisoning accounts for one-third of the world's suicide rate. In fact, in some parts of developing countries,...
The method of measuring the dispersion of an optically active molecule to determine the relative magnitude of right- or left-handed components and sometimes structural features of the molecule.
A dipolar ionic buffer.
Inorganic or organic compounds derived from phosphine (PH3) by the replacement of H atoms. (From Grant & Hackh's Chemical Dictionary, 5th ed)
The pH in solutions of proteins and related compounds at which the dipolar ions are at a maximum.
A method in which either the observer(s) or the subject(s) is kept ignorant of the group to which the subjects are assigned.