Artificial Nanometalloenzyme for Cooperative Tandem Catalysis.

08:00 EDT 15th April 2019 | BioPortfolio

Summary of "Artificial Nanometalloenzyme for Cooperative Tandem Catalysis."

Artificial metalloenzymes which combine the advantages of natural enzymes and metal catalysts have been getting more research attention. As a proof of concept, an artificial nanometalloenzyme (CALB-Shvo@MiMBN) was prepared by co-encapsulation of metallo-organic catalyst and enzyme in a soft nanocomposite consisting of 2-methylimidazole, metal ion, and biosurfactant in mild reaction conditions using one-pot self-assembly method. The artificial nanometalloenzyme with lipase acted as the core and metallo-organic catalyst embedded in micropore exhibited a spherical structure of 30-50 nm in diameter. The artificial nanometalloenzyme showed high catalytic efficiency in dynamic kinetic resolution of racemic primary amines or secondary alcohols, compared to one-pot catalytic reaction of immobilized lipase and free metallo-organic catalyst. This artificial nanometalloenzyme holds great promise for integrated enzymatic and heterogeneous catalysis.


Journal Details

This article was published in the following journal.

Name: ACS applied materials & interfaces
ISSN: 1944-8252


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