Co-delivery of Plasmid and Curcumin with Mesoporous Silica Nanoparticles for Promoting Neurite Outgrowth.

08:00 EDT 15th April 2019 | BioPortfolio

Summary of "Co-delivery of Plasmid and Curcumin with Mesoporous Silica Nanoparticles for Promoting Neurite Outgrowth."

Reactive oxygen species (ROS)-induced oxidative stress leads to neuron damage is involved in the pathogenesis of chronic inflammation in neurodegenerative diseases (NDs), such as Alzheimer's (AD), Parkinson's (PD) and amyotrophic lateral sclerosis (ALS). Researchers, therefore, are looking for anti-inflammatory drugs and gene therapy approaches to slow down or even prevent neurological disorders. Combining therapeutics have shown the synergistic effect in the treatment of human diseases. Many nanocarriers could be designed for simultaneous co-delivery of drugs with genes to fight diseases. However, only a few researches have been performed in NDs. In this study, we developed a mesoporous silica nanoparticle (MSN)-based approach for neurodegenerative therapy. This MSN-based platform involved multiple designs in targeted co-delivery of (1) curcumin, a natural antioxidant product, to protect ROS-induced cell damage, and (2) plasmid RhoG-DsRed, which is associated with the formation of lamellipodia and filopodia for promoting neurite outgrowth. At the same time, TAT peptide was introduced onto the plasmid RhoG-DsRed via electrostatic interaction to elevate the efficiency of non-endocytic pathways and nuclear plasmid delivery of RhoG-DsRed in cells for enhanced gene expression. Besides, such plasmid RhoG-DsRed/TAT complex could work as a noncovalent gatekeeper. The release of curcumin inside the channel of MSN could be triggered when the complex was dissociated from MSN surface. Taking together, this MSN-based platform combining genetic and pharmacological manipulations of actin cytoskeleton as well as oxidative stress provides an attractive way for NDs therapy.


Journal Details

This article was published in the following journal.

Name: ACS applied materials & interfaces
ISSN: 1944-8252


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