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Continuous-Flow Visible Light Organo-Photocatalysis for Direct Arylation of 2H-Indazoles: A Fast Access to Drug molecules.

08:00 EDT 15th April 2019 | BioPortfolio

Summary of "Continuous-Flow Visible Light Organo-Photocatalysis for Direct Arylation of 2H-Indazoles: A Fast Access to Drug molecules."

A continuous-flow homogeneous photocatalysis is devised for direct arylation of 2H-indazoles. This visible-light-promoted approach directly accesses a wide range of structurally diverse C3 arylated scaffolds of biological interests in a single-step and fast synthesis (1 min) manner under Eosin Y as a catalyst. Furthermore, we have employed this microreactor technology at metal-free conditions for the fast synthesis of inhibitor drugs of liver X-receptor with very good yields, whereas the reported methods required multi-steps and much longer reaction time (18 -24 h).

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Name: ChemSusChem
ISSN: 1864-564X
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