Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children.

08:00 EDT 15th April 2019 | BioPortfolio

Summary of "Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children."

Antigen specific IgE binds the Fcε receptor I (FcεRI) expressed on several types of immune cells, including dendritic cells (DC). Activation of FcεRI on DCs in atopics has been shown to modulate immune responses that potentially contribute to asthma development. However, the extent to which DC subsets differ in FcεRI expression between atopic children with or without asthma is currently not clear. This study aimed to analyse the expression of FcεRI on peripheral blood mononuclear cells (PBMC) from atopic children with and without asthma, and non-atopic/non-asthmatic age-matched healthy controls.


Journal Details

This article was published in the following journal.

Name: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
ISSN: 1399-3038


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