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The leaves of Lycium barbarum (LLB) have been utilized as crude drugs and functional tea for human health in China and Southeast Asia for thousands of years. To control its quality, a rapid and sensitive ultra-high performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry (UPLC-TQ-MS) method was established and validated for the first time for simultaneous determination of 10 phenolic acids and flavonoids (including neochlorogenic acid, protocatechuic aldehyde, p-hydroxybenzoic acid, chlorogenic acid, cryptochlorogenic acid, caffeic acid, p-coumaric acid, ferulic acid, rutin and kaempferol-3-O-rutinoside) in LLB. The separation was performed on an ACQUITY UPLC C chromatographic column (100 mm × 2.1 mm internal diameter, 1.7 μm particle size) with 0.1% formic acid in water (A) - acetonitrile (B) as the mobile phase under gradient elution. Multiple reaction monitoring (MRM) mode was adopted to simultaneously monitor the target components. The developed method was fully validated in terms of linearity (r ≥0.9860), precision (RSD≤6.58%), repeatability (RSD≤6.60%), stability (RSD≤6.17%), recovery (95.56%~108.06%, RSD≤4.64%) as well as limit of detection (0.021~0.664 ng/mL) and limit of quantity (0.069~2.210 ng/mL), and then successfully applied to evaluate the quality of 64 batches of LLB collected from 41 producing areas in 4 different provinces of China. The results showed that the LLB, especially collected from Inner Mongolia regions, were rich in the phenolic acids and flavonoids. Rutin, kaempferol-3-O-rutinoside and chlorogenic acid are the predominant compounds contained in LLB. The above findings will provide helpful information for the effective utilization of LLB.
This article was published in the following journal.
Name: Biomedical chromatography : BMC
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A plant genus of the family OLEACEAE. Oleuropein, a phenolic secoiridoid glycoside, is found in the leaves.
A class of phenolic acids related to chlorogenic acid, p-coumaric acid, vanillic acid, etc., which are found in plant tissues. It is involved in plant growth regulation.
A plant genus of the family SOLANACEAE. Members contain CEREBROSIDES and SCOPOLETIN.
A collective name for a group of closely related lipids that contain substitutions on the 2H-1-benzopyran-6-ol nucleus and a long hydrocarbon chain of isoprenoid units. They are antioxidants by virtue of the phenolic hydrogen. Tocopherols react with the most reactive form of oxygen and protect unsaturated fatty acids from oxidation.
A plant genus of the family ANACARDIACEAE. This is the source of the familiar cashew nuts, which are heat treated to remove the irritant toxin. Cashew nut shell liquid (frequently abbreviated as CNSL) is a major source of alkenyl phenolic compounds, especially ANACARDIC ACIDS, cardol, and cardanol.
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