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Inhibition of autophagy alleviates cadmium-induced mouse spleen and human B cells apoptosis.

08:00 EDT 15th April 2019 | BioPortfolio

Summary of "Inhibition of autophagy alleviates cadmium-induced mouse spleen and human B cells apoptosis."

Cadmium (Cd) is a toxic heavy metal that can accumulate and cause severe damage to many organs, such as liver, kidney, lung, etc. Cd also significantly suppresses immunity, however, the underlying mechanism involved in Cd-induced immunnotoxicity is still unclear. The present study indicated that semi-chronic Cd exposure (7 days) induced apoptotic damage of mouse spleen. In human Ramos B cells, Cd exposure also induced apoptosis, which was dependent on Cd induced vacuole membrane protein 1 (VMP1) expression and autophagy. Cd induced autophagy and apoptosis was abated when VMP1 expression was knockdown. In addition, Cd-induced VMP1 expression, autophagy and apoptosis were dependent on the elevation of Ca2+ and reactive oxygen species (ROS). More important, Cd exposure also induced VMP1 expression and autophagy in mouse spleen tissue, and the intraperitoneal injection of the autophagy inhibitor chloroquine (CQ) into mice effectively reduced Cd induced spleen apoptotic damage. Taken together, these results indicate Cd induced autophagy, promotes apoptosis in immune cells, and inhibition of autophagy can alleviate Cd induced spleen and immune cell apoptosis. This study might provide the groundwork for future studies on Cd induced immunomodulatory effects and immune diseases.

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This article was published in the following journal.

Name: Toxicological sciences : an official journal of the Society of Toxicology
ISSN: 1096-0929
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An autophagy related protein that is similar to UBIQUITIN-ACTIVATING ENZYME E1. It functions in CYTOPLASM to VACUOLE transport (Cvt) and AUTOPHAGY by activating ATG12 PROTEIN for its conjugation with ATG5 PROTEIN, as well as the conjugation of ATG8 FAMILY PROTEINS with phosphatidylethanolamine for ATG8 association to Cvt vesicles and AUTOPHAGOSOME membranes. It is also required for the nitrogen starvation response in yeast, MITOPHAGY; and autophagic cell death induced by CASPASE 8 inhibition.

Unstable isotopes of cadmium that decay or disintegrate emitting radiation. Cd atoms with atomic weights 103-105, 107, 109, 115, and 117-119 are radioactive cadmium isotopes.

Inorganic compounds that contain cadmium as an integral part of the molecule.

Poisoning occurring after exposure to cadmium compounds or fumes. It may cause gastrointestinal syndromes, anemia, or pneumonitis.

An element with atomic symbol Cd, atomic number 48, and atomic weight 114. It is a metal and ingestion will lead to CADMIUM POISONING.

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