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Abdominal vagal deafferentation alters affective behaviors in rats.

08:00 EDT 7th April 2019 | BioPortfolio

Summary of "Abdominal vagal deafferentation alters affective behaviors in rats."

There is growing evidence for a role of abnormal gut-brain signaling in disorders involving altered mood and affect, including depression. Studies using vagus nerve stimulation (VNS) suggest that the disruption of vagal afferent signaling may contribute to these abnormalities. To test this hypothesis, we used a rat model of subdiaphragmatic vagal deafferentation (SDA), the most complete and selective vagal deafferentation method existing to date, to study the consequences of complete disconnection of abdominal vagal afferents on affective behaviors.

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This article was published in the following journal.

Name: Journal of affective disorders
ISSN: 1573-2517
Pages: 404-412

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