Exploitation of the Ugi-Joullié reaction in drug discovery and development.

08:00 EDT 19th April 2019 | BioPortfolio

Summary of "Exploitation of the Ugi-Joullié reaction in drug discovery and development."

Multicomponent reactions are paramount in drug discovery for their ability to achieve high levels of diversity within the chemical space, generating complex structures from simple building blocks. Among them, the isocyanide-based Ugi-Joulliè reaction is particularly suited for the rapid synthesis of peptidomimetics and nitrogen-containing compounds. Areas covered: The latest achievements in drug discovery and synthetic chemistry regarding the application of the Ugi-Joulliè reaction in the field of natural compounds, peptidomimetics and small molecules, are reported in this article. All relevant literature was disclosed applying most common web-based literature searching tools, namely Web of Science, PubMed, SciFinder and Google Scholar. Expert opinion: The Ugi-Joulliè reaction represents an extremely versatile and simple synthetic methodology, useful for designing efficiently new molecular frameworks. Particularly relevant to drug discovery is the Ugi-Joulliè-based synthesis of conformationally constrained peptidomimetics and antibacterial depsipeptides. On the other hand, the many syntheses of new, nitrogen-containing heterocycles are not always followed by biological evaluation, losing opportunities for the disclosure of unprecedented lead compounds.


Journal Details

This article was published in the following journal.

Name: Expert opinion on drug discovery
ISSN: 1746-045X
Pages: 1-14


DeepDyve research library

PubMed Articles [21768 Associated PubMed Articles listed on BioPortfolio]

An overview of late-stage functionalization in today's drug discovery.

: Late-stage functionalization (LSF) can introduce important chemical groups in the very last steps of the synthesis. LSF has the potential to speed up the preparation of novel chemical entities and d...

Reliability of Click Chemistry on Drug Discovery: A Personal Account.

The unprecedented efficiency, reliability and adaptability in drug discovery, with the growing number of applications and impact, have made Click Chemistry fascinating to the scientific community. The...

Concepts of Artificial Intelligence for Computer-Assisted Drug Discovery.

Artificial intelligence (AI), and, in particular, deep learning as a subcategory of AI, provides opportunities for the discovery and development of innovative drugs. Various machine learning approache...

The importance of target binding kinetics for measuring target binding affinity in drug discovery: a case study from a CRF receptor antagonist program.

In drug discovery, it is essential to accurately measure drug-target binding affinity. Here, we revisit the fact that target binding kinetics impact the measurement of affinity, using a case study: de...

Discovery of Noncancer Drug Effects on Survival in Electronic Health Records of Patients With Cancer: A New Paradigm for Drug Repurposing.

Drug development is becoming increasingly expensive and time consuming. Drug repurposing is one potential solution to accelerate drug discovery. However, limited research exists on the use of electron...

Clinical Trials [6088 Associated Clinical Trials listed on BioPortfolio]

Allergic Versus Non Allergic Hypersensitivity Drug Reaction (BdDAllergo)

The creation of a database containing the medical data of patients followed in allergology at the University Hospital of Grenoble will permit to study allergic versus non-allergic hypersen...

Adverse Drug Reactions With Fatal Outcome

The purpose of this study is to determine the incidence of drug-related deaths in a university hospital during the year 2015

Drug Patch Tests in Patients With Severe Cutaneous Adverse Reaction to Drugs (SCARs)

The study is about drug patch tests in patients who have history of severe cutaneous drug reaction including Steven Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), Drug induced e...

Girl Empower: Studying the Impact of Mentorship, Asset Building, Caregiver Discussion Groups, and Cash Transfers on Reducing Girl's Vulnerability to Sexual Exploitation and Abuse

Girl Empower (GE) is a program designed to equip girls with the skills and experiences necessary to make healthy, strategic life choices and to stay safe from sexual exploitation and abuse...

Induced Pluripotent Stem Cells for the Development of Novel Drug Therapies for Inborn Errors of Metabolism (iPSC-IEM)

Human induced pluripotent stem cells (iPSCs), are reprogrammed from somatic cells that can self-renew indefinitely and produce different types of cells. They provide human model cell lines...

Medical and Biotech [MESH] Definitions

The process of finding chemicals for potential therapeutic use.

Directions written to discontinue use of PRESCRIPTION DRUGS in order to reduce unnecessary and/or excessive medications (see POLYPHARMACY), DRUG SIDE EFFECTS and ADVERSE DRUG REACTION.

Measurable biological parameters that serve for drug development, safety and dosing (DRUG MONITORING).

Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions.

Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.

Quick Search

DeepDyve research library

Relevant Topics

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

Biological Therapy
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...

Searches Linking to this Article