Positive Airway Pressure Therapy Reduces Pulmonary Hypertension in Patients Admitted for Acute Heart Failure with Pulmonary Hypertension and Obstructive Sleep Apnea. The ASAP-HF Pilot Trial.

08:00 EDT 20th April 2019 | BioPortfolio

Summary of "Positive Airway Pressure Therapy Reduces Pulmonary Hypertension in Patients Admitted for Acute Heart Failure with Pulmonary Hypertension and Obstructive Sleep Apnea. The ASAP-HF Pilot Trial."

Pulmonary hypertension(PH) is extremely common in acute decompensated heart failure (ADHF) patients and predicts increased mortality. Obstructive sleep apnea (OSA) is highly prevalent in CHF patients, may contribute to further elevated pulmonary pressures.


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This article was published in the following journal.

Name: Sleep
ISSN: 1550-9109


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Medical and Biotech [MESH] Definitions

A technique of respiratory therapy, in either spontaneously breathing or mechanically ventilated patients, in which airway pressure is maintained above atmospheric pressure throughout the respiratory cycle by pressurization of the ventilatory circuit. (On-Line Medical Dictionary [Internet]. Newcastle upon Tyne(UK): The University Dept. of Medical Oncology: The CancerWEB Project; c1997-2003 [cited 2003 Apr 17]. Available from:

Non-therapeutic positive end-expiratory pressure occurring frequently in patients with severe airway obstruction. It can appear with or without the administration of external positive end-expiratory pressure (POSITIVE-PRESSURE RESPIRATION). It presents an important load on the inspiratory muscles which are operating at a mechanical disadvantage due to hyperinflation. Auto-PEEP may cause profound hypotension that should be treated by intravascular volume expansion, increasing the time for expiration, and/or changing from assist mode to intermittent mandatory ventilation mode. (From Harrison's Principles of Internal Medicine, 12th ed, p1127)

Application of positive pressure to the inspiratory phase when the patient has an artificial airway in place and is connected to a ventilator.

A type of oropharyngeal airway that provides an alternative to endotracheal intubation and standard mask anesthesia in certain patients. It is introduced into the hypopharynx to form a seal around the larynx thus permitting spontaneous or positive pressure ventilation without penetration of the larynx or esophagus. It is used in place of a facemask in routine anesthesia. The advantages over standard mask anesthesia are better airway control, minimal anesthetic gas leakage, a secure airway during patient transport to the recovery area, and minimal postoperative problems.

The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.

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