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Transcriptome-based identification of lovastatin as a breast cancer stem cell-targeting drug.

07:00 EST 16th February 2019 | BioPortfolio

Summary of "Transcriptome-based identification of lovastatin as a breast cancer stem cell-targeting drug."

Breast cancer is a neoplastic disease with high morbidity and mortality in women worldwide. Breast cancer stem cells (CSCs) have a significant function in tumor growth, recurrence, and therapeutic resistance. Thus, CSCs have been pointed as targets of new therapies for breast cancer. Herein, we aimed to repurpose certain drugs as breast CSC-targeting agents.

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Journal Details

This article was published in the following journal.

Name: Pharmacological reports : PR
ISSN: 1734-1140
Pages: 535-544

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Medical and Biotech [MESH] Definitions

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Metastatic breast cancer characterized by EDEMA and ERYTHEMA of the affected breast due to LYMPHATIC METASTASIS and eventual obstruction of LYMPHATIC VESSELS by the cancer cells.

The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)

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