Topics

Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes.

08:00 EDT 3rd May 2019 | BioPortfolio

Summary of "Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes."

The aim of this study was to investigate the association of epicardial (EAT) and pericardial (PAT) adipose tissues with myocardial function in type 2 diabetes (T2D). EAT and PAT were measured by ultrasound in 770 patients with T2D and 234 age and sex-matched non-diabetic controls. Echocardiography was performed, including tissue Doppler imaging and 2D speckle tracking. Patients with T2D vs. controls had increased EAT (4.6±1.8 mm vs. 3.4±1.2 mm, p<0.0001) and PAT (6.3±2.8 mm vs. 5.3±2.4 mm, p<0.0001). EAT and PAT were associated with structural cardiac measures both in T2D patients and controls (all p<0.043), but only in T2D patients with functional measures: PAT was associated with impaired global longitudinal strain (beta coefficient (SE)) (0.11% (0.04), p=0.002), while EAT was associated with reduced diastolic function by lateral e'(-0.31 (0.05) cm/s, p=0.001), E/A ratio (-0.02 (0.01), p=0.001), and lateral E/e' (0.36, (0.10), p<0.001). However, no interaction was found between diabetes status and PAT (p=0.75) or EAT (p=0.45). Adipose tissue in intimate relation to the myocardium is higher in patients with T2D vs. controls and associated with functional myocardial measures in T2D. This article is protected by copyright. All rights reserved.

Affiliation

Journal Details

This article was published in the following journal.

Name: Diabetes, obesity & metabolism
ISSN: 1463-1326
Pages:

Links

DeepDyve research library

PubMed Articles [9500 Associated PubMed Articles listed on BioPortfolio]

High released lactate by epicardial fat from coronary artery disease patients is reduced by dapagliflozin treatment.

Dapagliflozin, a sodium-glucose co-transporter 2 inhibitor, improves glucose uptake by epicardial adipose tissue (EAT). However, its metabolism might raise the lactate production and acidosis under hy...

Myocardial adipose deposition and the development of heart failure with preserved ejection fraction.

It has been proposed that an increase of myocardial adiposity is related to left ventricular (LV) diastolic dysfunction. The specific roles of myocardial steatosis including epicardial fat and intramy...

Epicardial Adipose Tissue Thickness as an Independent Predictor of Ventricular Tachycardia Recurrence Following Ablation.

Although several investigations have shown a relationship between increased epicardial adipose tissue (EAT) and atrial fibrillation (AF), the association between EAT and ventricular tachycardia (VT) h...

Epicardial Adipose Thickness in Youth with Type 1 Diabetes.

Epicardial adipose thickness (EAT) is increased in adults with type 1 diabetes (T1D) and is thought to contribute to cardiovascular disease (CVD) in this population. Given that CVD risk factors emerge...

Quantification of epicardial adipose tissue by cardiac CT: Influence of acquisition parameters and contrast enhancement.

While computed tomography (CT) is frequently used to quantify epicardial adipose tissue (EAT), the effect of different acquisition parameters on EAT volume has not been systematically reported. We ass...

Clinical Trials [4075 Associated Clinical Trials listed on BioPortfolio]

Relation of Epicardial Fat and Diabetic Nephropathy in Egyptian Patients

The heart and vessels are surrounded by layers of adipose tissue, which is a complex organ composed of adipocytes, stromal cells, macrophages, and a neuronal network, all nourished by a ri...

Rook Epicardial Access Device Study

The purpose of this study is to confirm the efficacy and safety of the Talon Surgical Rook® Epicardial Access Kit as a pericardial access device. The Rook® Epicardial Access Kit will be ...

Ertugliflozin: Cardioprotective Effects on Epicardial Fat

The purpose of this study is to learn if Sodium-Glucose Cotransporter 2 inhibitor (SGLT2i) medications enhance beneficial properties of epicardial adipose tissue including metabolic flexib...

Influence of EPICardial Adipose Tissue in HEART Diseases: EPICHEART Study

This translational study was designed to explore the association of the quantity and quality of epicardial adipose tissue (EAT) with coronary artery disease (CAD), left atrial remodeling a...

Semaglutide vs Dulaglutide on Epicardial Adipose Tissue

Epicardial Fat (EAT), the visceral fat depot of the heart, is a modifiable cardio-metabolic risk factor and therapeutic target. EAT expresses GLP-1 receptors (GLP-1R). GLP-1 receptor agoni...

Medical and Biotech [MESH] Definitions

A centrally acting antihypertensive agent. The drug lowers both systolic and diastolic blood pressure by activating the central nervous system alpha-2 adrenoreceptors, which results in reduced sympathetic outflow leading to reduced vascular tone. Its adverse reactions include dry mouth, sedation, and constipation.

Surgical construction of an opening or window in the pericardium. It is often called subxiphoid pericardial window technique.

Brown fat-like adipose tissue that develops in WHITE ADIPOSE TISSUE from non-MYOGENIC REGULATORY FACTOR 5 expressing cell lineage.

Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associated with trauma. Lipid-containing effusion (chylopericardium) results from leakage of THORACIC DUCT. Severe cases can lead to CARDIAC TAMPONADE.

Inflammation of the connective and adipose tissues surrounding the KIDNEY.

Quick Search


DeepDyve research library

Relevant Topic

Radiology
Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...


Searches Linking to this Article