The physiological determinants of near-infrared spectroscopy-derived regional cerebral oxygenation in critically ill adults.

08:00 EDT 2nd May 2019 | BioPortfolio

Summary of "The physiological determinants of near-infrared spectroscopy-derived regional cerebral oxygenation in critically ill adults."

To maintain adequate oxygen delivery to tissue, resuscitation of critically ill patients is guided by assessing surrogate markers of perfusion. As there is no direct indicator of cerebral perfusion used in routine critical care, identifying an accurate strategy to monitor brain perfusion is paramount. Near-infrared spectroscopy (NIRS) is a non-invasive technique to quantify regional cerebral oxygenation (rSO) that has been used for decades during cardiac surgery which has led to targeted algorithms to optimize rSO being developed. However, these targeted algorithms do not exist during critical care, as the physiological determinants of rSO during critical illness remain poorly understood.


Journal Details

This article was published in the following journal.

Name: Intensive care medicine experimental
ISSN: 2197-425X
Pages: 23


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Medical and Biotech [MESH] Definitions

A noninvasive technique that uses the differential absorption properties of hemoglobin and myoglobin to evaluate tissue oxygenation and indirectly can measure regional hemodynamics and blood flow. Near-infrared light (NIR) can propagate through tissues and at particular wavelengths is differentially absorbed by oxygenated vs. deoxygenated forms of hemoglobin and myoglobin. Illumination of intact tissue with NIR allows qualitative assessment of changes in the tissue concentration of these molecules. The analysis is also used to determine body composition.

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