A systematic review of existing peripheral biomarkers of cognitive aging: Is there enough evidence for biomarker proxies in behavioral modification interventions?: An initiative in association with the Nutrition, Exercise and Lifestyle Team of the Canadian Consortium of Neurodegeneration in Aging.

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Summary of "A systematic review of existing peripheral biomarkers of cognitive aging: Is there enough evidence for biomarker proxies in behavioral modification interventions?: An initiative in association with the Nutrition, Exercise and Lifestyle Team of the Canadian Consortium of Neurodegeneration in Aging."

Peripheral biomarkers have shown significant value in predicting brain health and may be serve as useful proxy measurements in the assessment of evidence-based lifestyle behavior modifications, including physical activity and a healthy diet patterns, that aim to maintain cognitive function in late life. The aim of this systematic review was to elucidate which peripheral biomarkers are robustly associated with cognitive function in late life, among relatively healthy non-demented older adults. Following the standards for systematic reviews (PICO, PRIMSA), and employing Medline and Scopus search engines, 222 articles were included in the review. Based on the review of biomarker proxies of cognitive health, it is recommended that a comprehensive biomarker panel, or biomarker signature, be developed as a clinical end point for behavior modification trials aimed at enhancing cognitive function in late life. The biomarker signature should take a multisystemic approach, including lipid, immune/inflammatory, and metabolic biomarkers in the biological signature index of cognitive health.


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This article was published in the following journal.

Name: Ageing research reviews
ISSN: 1872-9649


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